Near-infrared spectroscopic study of frontopolar activation during face-to-face conversation in major depressive disorder and bipolar disorder
| Autor: | Tomokazu Motegi, Miho Yamaguchi, Minami Tagawa, Kosuke Narita, Yoshiyuki Aoyama, Yuichi Takei, Masato Fukuda, Noriko Sakurai, Masashi Suda |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Global Assessment of Functioning Audiology Neuropsychological Tests behavioral disciplines and activities Brain mapping Temporal lobe Young Adult mental disorders medicine Humans Speech Interpersonal Relations Bipolar disorder Psychiatry Biological Psychiatry Psychiatric Status Rating Scales Brain Mapping Depressive Disorder Major Spectroscopy Near-Infrared Middle Aged medicine.disease Temporal Lobe Frontal Lobe Psychiatry and Mental health Frontal lobe Mood disorders Schizophrenia Case-Control Studies Oxyhemoglobins Major depressive disorder Female Psychology |
| Zdroj: | Journal of psychiatric research. 57 |
| ISSN: | 1879-1379 |
| Popis: | Major depressive disorder (MDD) and bipolar disorder (BD) patients show speech characteristics that vary greatly according to mood state. In a previous study, we found impaired temporal and right inferior frontal gyrus (IFG) activation in schizophrenia during face-to-face conversation; no study had, however, previously investigated mood disorders during face-to-face conversation. Here, we investigated frontal and temporal lobe activation during conversation in patients with MDD and BD. Frontal and temporal lobe activation was measured using near-infrared spectroscopy (NIRS) in 29 patients with MDD, 31 patients with BD, and 31 normal controls (NC). We compared continuous activation and rapid change of activation with talk/listen phase changes during the conversation and analyzed the correlation between these indices and clinical variables. Both the MDD and BD groups showed decreased continuous activation in the left dorsolateral prefrontal (DLPFC) and left frontopolar cortices (FPCs); they also showed decreased rapid change in bilateral FPC activation. In the MDD group, the rapid change of activation was positively correlated with Global Assessment of Functioning (GAF) scores. In the BD group, continuous activation was negatively correlated with age of onset. These results indicate that frontal activation during conversation decreases in both MDD and BD. However, both continuous activation and rapid change may reflect the pathophysiological character of MDD and BD; in particular, the reduced amount of rapid change in the right FPC may be related to impaired adaptive ability in MDD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect