Role of BAG3 in cancer progression: A therapeutic opportunity
| Autor: | Paolo Remondelli, Gianluca Sala, Anna Basile, Alessandra Rosati, Liberato Marzullo, Antonia Falco, Michelina Festa, Vittoria Iorio, Pierpaolo Cavallo, Maria Pascale, Vincenzo De Laurenzi, Margot De Marco, Bianca Ranieri, Raffaele Pezzilli, Maria Caterina Turco, Matthew A. Firpo, Mario Capunzo |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
BAG domain Cell Apoptosis BAG3 Mechanotransduction Cellular WW domain 03 medical and health sciences Protein Domains Heat shock protein Paracrine Communication Autophagy Biomarkers Tumor medicine Humans HSP70 Heat-Shock Proteins Mechanotransduction Receptor Adaptor Proteins Signal Transducing biology Macrophages Membrane Proteins Cell Biology Pancreatic Neoplasms 030104 developmental biology medicine.anatomical_structure Cancer research biology.protein Apoptosis Regulatory Proteins Carcinoma Pancreatic Ductal Developmental Biology |
| Zdroj: | Seminars in Cell & Developmental Biology. 78:85-92 |
| ISSN: | 1084-9521 |
| DOI: | 10.1016/j.semcdb.2017.08.049 |
| Popis: | BAG3 is a multifunctional protein that can bind to heat shock proteins (Hsp) 70 through its BAG domain and to other partners through its WW domain, proline-rich (PXXP) repeat and IPV (Ile-Pro-Val) motifs. Its intracellular expression can be induced by stressful stimuli, while is constitutive in skeletal muscle, cardiac myocytes and several tumour types. BAG3 can modulate the levels, localisation or activity of its partner proteins, thereby regulating major cell pathways and functions, including apoptosis, autophagy, mechanotransduction, cytoskeleton organisation, motility. A secreted form of BAG3 has been identified in studies on pancreatic ductal adenocarcinoma (PDAC). Secreted BAG3 can bind to a specific receptor, IFITM2, expressed on macrophages, and induce the release of factors that sustain tumour growth and the metastatic process. BAG3 neutralisation therefore appears to constitute a novel potential strategy in the therapy of PDAC and, possibly, other tumours. |
| Databáze: | OpenAIRE |
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