Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances
| Autor: | Michael R. Hamblin, Mohammad Amiri, Mahnaz Bozorgomid, Amir Ghasemi, Hadi Ghahramanzadeh Asl, Mahdi Karimi, Mohammad Reza Rahmani Taji Boyuk, Parham Sahandi Zangabad, Mohsen Bahrami, Alireza Ghasemi, Zahra Mahdieh, Hedieh Malekzad |
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| Rok vydání: | 2016 |
| Předmět: |
Drug Carriers
Materials science Polymers Temperature Nanotechnology 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Controlled release Article 0104 chemical sciences Drug Delivery Systems Targeted drug delivery On demand Nanoparticles General Materials Science Nanocarriers 0210 nano-technology Drug carrier |
| Zdroj: | ACS Applied Materials & Interfaces. 8:21107-21133 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.6b00371 |
| Popis: | Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as carriers that can be stimulated by changes in environmental parameters such as temperature, pH, light, electromagnetic fields, mechanical forces, etc. These smart nanocarriers can release their cargo on demand when their target is reached and the stimulus is applied. Using the techniques of nanotechnology, these nanocarriers can be tailored to be target-specific, and exhibit delayed or controlled release of drugs. Temperature-responsive nanocarriers are one of most important groups of smart nanoparticles (NPs) that have been investigated during the past decades. Temperature can either act as an external stimulus when heat is applied from the outside, or can be internal when pathological lesions have a naturally elevated termperature. A low critical solution temperature (LCST) is a special feature of some polymeric materials, and most of the temperature-responsive nanocarriers have been designed based on this feature. In this review, we attempt to summarize recent efforts to prepare innovative temperature-responsive nanocarriers and discuss their novel applications. |
| Databáze: | OpenAIRE |
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