Widening control of fin inter‐rays in zebrafish and inferences about actinopterygian fins
| Autor: | Manuel Marí-Beffa, J. Ruiz-Sánchez, Juan Antonio Hijano, Flores Martín-Reyes, Javier Gutiérrez, Salvador Cazorla‐Vázquez, Tahia D. Fernandez, Carmen Murciano, Laura Mesa‐Almagro |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Histology Fin Gene Expression knck5b Biology Animals Genetically Modified Fin regeneration 03 medical and health sciences Potassium Channels Tandem Pore Domain Cell Movement euteleostei Animals Regeneration Hedgehog Proteins Receptor Fibroblast Growth Factor Type 1 Molecular Biology Zebrafish Ecology Evolution Behavior and Systematics inter-ray fibroblast growth factor receptor 1 Regeneration (biology) fin regeneration Fish fin evo-devo Cell migration Original Articles Cell Biology Zebrafish Proteins biology.organism_classification Hedgehog signaling pathway Cell biology 030104 developmental biology Animal Fins Evolutionary developmental biology Female Anatomy actinopterygii Developmental Biology |
| Zdroj: | J Anat |
| ISSN: | 1469-7580 0021-8782 |
| DOI: | 10.1111/joa.12785 |
| Popis: | The amputation of a teleost fin rapidly triggers an intricate maze of hierarchically regulated signalling processes which ultimately reconstruct the diverse tissues of the appendage. Whereas the generation of the fin pattern along the proximodistal axis brings with it several well-known developmental regulators, the mechanisms by which the fin widens along its dorsoventral axis remain poorly understood. Utilizing the zebrafish as an experimental model of fin regeneration and studying more than 1000 actinopterygian species, we hypothesized a connection between specific inter-ray regulatory mechanisms and the morphological variability of inter-ray membranes found in nature. To tackle these issues, both cellular and molecular approaches have been adopted and our results suggest the existence of two distinguishable inter-ray areas in the zebrafish caudal fin, a marginal and a central region. The present work associates the activity of the cell membrane potassium channel kcnk5b, the fibroblast growth factor receptor 1 and the sonic hedgehog pathway to the control of several cell functions involved in inter-ray wound healing or dorsoventral regeneration of the zebrafish caudal fin. This ray-dependent regulation controls cell migration, cell-type patterning and gene expression. The possibility that modifications of these mechanisms are responsible for phenotypic variations found in euteleostean species, is discussed. |
| Databáze: | OpenAIRE |
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