Use of seed gums from Tamarindus indica and Cassia fistula as controlled-release agents
| Autor: | Wancheng Sittikijyothin, Kampanart Huanbutta |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pharmaceutical Science
Carboxymethylated gum 02 engineering and technology Seed gum 010402 general chemistry 01 natural sciences Diluent Matrix (chemical analysis) Cassia Cassia fistula medicine Fourier transform infrared spectroscopy Swelling Controlled-release agent Pharmacology Chromatography biology Tamarindus indica Chemistry lcsh:RM1-950 food and beverages Diclofenac Sodium 021001 nanoscience & nanotechnology biology.organism_classification Controlled release 0104 chemical sciences Original Research Paper lcsh:Therapeutics. Pharmacology medicine.symptom 0210 nano-technology Compression time |
| Zdroj: | Asian Journal of Pharmaceutical Sciences, Vol 13, Iss 5, Pp 398-408 (2018) Asian Journal of Pharmaceutical Sciences |
| ISSN: | 1818-0876 |
| Popis: | Most seed gums have been widely used in oral and topical pharmaceutical formulations, cosmetics, and food products because of their hydrophilic properties. Gums from Tamariudus indica and Cassia fistula seeds were chemically modified by carboxymethylation to improve their functionalities. The objective of the present study was to characterize and evaluate crude and carboxymethylated gums from T. indica and C. fistula seeds to achieve the controlled-release of diclofenac sodium (DS) in matrix tablet form. Both crude and carboxymethylated gums were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy. The results revealed that the gums were successfully modified by carboxymethylation and that the modified gums were amorphous in structure and had better flow properties. The carboxymethylated gums from both plant seeds did not exhibit cytotoxicity at concentrations lower than 0.5 mg/ml. All gum samples used as polymeric controlled-release agents were formulated into DS matrix tablets. Hardness and thickness tests were conducted as in-process tests. Drug content estimation and in vitro drug release studies were carried out to evaluate the matrix tablets. Increasing the concentration of gums increased compression time and hardness while it reduced the thickness. Furthermore, the results fitted well with the Korsmeyer–Peppas model. Moreover, the DS tablets were found to release the drug by super case II transport (relaxation). In summary, the carboxymethylated gum from T. indica and C. fistula seeds is an excellent, naturally sourced gum with high physicochemical and functional qualities, and can potentially be used in pharmaceutical applications as a disintegrant, diluent, and drug release-controlling agent. Graphical abstract Image, graphical abstract |
| Databáze: | OpenAIRE |
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