Predictive and Prognostic Factors in Ovarian and Uterine Carcinosarcomas

Autor: İrfan Cicin, Tahsin Özatlı, Esma Türkmen, Türkan Özturk, Melike Özçelik, Devrim Çabuk, Ayşe Gökdurnalı, Özlem Balvan, Yaşar Yıldız, Metin Şeker, Nuriye Özdemir, Burcu Yapar, Özgür Tanrıverdi, Yusuf Günaydin, Serkan Menekşe, Berna Öksüzoğlu, Asude Aksoy, Bülent Erdoğan, M. Bekir Hacıoglu, Erkan Arpaci, Alper Sevinç, Mehmet Atilla Uysal, Sinem İliaz
Přispěvatelé: Sivas Cumhuriyet Üniversitesi, [Cicin, Irfan -- Turkmen, Esma -- Erdogan, Bulent -- Hacioglu, M. Bekir] Trakya Univ, Sch Med, Dept Med Oncol, Edirne, Turkey -- [Ozatli, Tahsin -- Gokdurnali, Ayse -- Oksuzoglu, Berna] Ankara Dr Abdurrahman Yurtaslan Oncol Training &, Dept Med Oncol, Ankara, Turkey -- [Ozturk, Turkan] Karadeniz Tech Univ, Dept Med Oncol, Sch Med, Trabzon, Turkey -- [Ozcelik, Melike -- Balvan, Ozlem] Dr Lutfi Kirdar Res & Training Hosp, Dept Med Oncol, Istanbul, Turkey -- [Cabuk, Devrim] Kocaeli Univ, Sch Med, Dept Med Oncol, Kocaeli, Turkey -- [Yildiz, Yasar] Ataturk Training & Res Hosp, Dept Med Oncol, Izmir, Turkey -- [Seker, Metin] Cumhuriyet Univ, Dept Med Oncol, Sch Med, Sivas, Turkey -- [Ozdemir, Nuriye] Ankara Numune Training & Res Hosp, Dept Med Oncol, Ankara, Turkey -- [Yapar, Burcu] Pamukkale Univ, Dept Med Oncol, Sch Med, Denizli, Turkey -- [Tanriverdi, Ozgur] Mugla Univ, Dept Med Oncol, Sch Med, Mugla, Turkey -- [Gunaydin, Yusuf] Gazi Univ, Dept Med Oncol, Sch Med, Ankara, Turkey -- [Menekse, Serkan] Celal Bayar Univ, Dept Med Oncol, Sch Med, Manisa, Turkey -- [Aksoy, Asude] Inonu Univ, Dept Med Oncol, Sch Med, Malatya, Turkey -- [Arpaci, Erkan] Sakarya Res & Training Hosp, Dept Med Oncol, Sakarya, Turkey -- [Sevinc, Alper] Gaziantep Univ, Dept Med Oncol, Sch Med, Gaziantep, Turkey, aksoy, asude -- 0000-0002-5609-9658, MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tanrıverdi, Özgür
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Oncology
predictive factors
endocrine system diseases
medicine.medical_treatment
retrospective study
platinum complex
lcsh:Medicine
medical record review
pelvis lymph node
Turkey (republic)
chemoradiotherapy
0302 clinical medicine
Carcinosarcoma
Stage (cooking)
Lymph node
antineoplastic agent
Cerrahi
Carcinosarcoma
ovary
uterine
predictive factors
prognostic factors

cancer adjuvant therapy
Standard treatment
adult
ovary cancer
uterine
General Medicine
ovarian carcinosarcoma
female genital diseases and pregnancy complications
uterus cancer
Serous fluid
Uterine
aged
medicine.anatomical_structure
female
030220 oncology & carcinogenesis
Original Article
adjuvant radiotherapy
Predictive factors
medicine.medical_specialty
overall survival
brachytherapy
tumor localization
carcinosarcoma
lymph node dissection
paraaortic lymph node
ovary
prognostic factors
Prognostic factors
clinical observation
uterine carcinosarcoma
cancer prognosis
Article
03 medical and health sciences
Internal medicine
medicine
cross-sectional study
controlled study
human
survival time
Chemotherapy
business.industry
cancer staging
lcsh:R
Ovary
prediction
medicine.disease
cancer classification
major clinical study
Radiation therapy
drug efficacy
030104 developmental biology
age
minimal residual disease
business
Clear cell
Zdroj: Balkan Medical Journal, Vol 33, Iss 5, Pp 517-524 (2016)
Volume: 33, Issue: 5 517-524
Balkan Medical Journal
ISSN: 0003-8474
2146-3123
Popis: WOS: 000384744100006
PubMed ID: 27761279
Background: Prognostic factors and the standard treatment approach for gynaecological carcinosarcomas have not yet been clearly defined. Although carcinosarcomas are more aggressive than pure epithelial tumours, they are treated similarly. Serous/clear cell and endometrioid components may be predictive factors for the efficacy of adjuvant chemotherapy (CT) or radiotherapy (RT) or RT in patients with uterine and ovarian carcinosarcomas. Heterologous carcinosarcomas may benefit more from adjuvant CT. Aims: We aimed to define the prognostic and predictive factors associated with treatment options in ovarian (OCS) and uterine carcinosarcoma (UCS). Study Design: Retrospective cross-sectional study Methods: We retrospectively reviewed the medical records of patients with ovarian and uterine carcinosarcoma from 2000 to 2013, and 127 women were included in this study (24 ovarian and 103 uterine). Patients admitted to seventeen oncology centres in Turkey between 2000 and December 2013 with a histologically proven diagnosis of uterine carcinosarcoma with FIGO 2009 stage I-III and patients with sufficient data obtained from well-kept medical records were included in this study. Stage IV tumours were excluded. The patient records were retrospectively reviewed. Data from 104 patients were evaluated for this study. Results: Age (>= 70 years) was a poor prognostic factor for UCS (p=0.036). Pelvic +/- para aortic lymph node dissection did not affect overall survival (OS) (p=0.35). Macroscopic residual disease was related with OS (p
Databáze: OpenAIRE
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