Predictive and Prognostic Factors in Ovarian and Uterine Carcinosarcomas
Autor: | İrfan Cicin, Tahsin Özatlı, Esma Türkmen, Türkan Özturk, Melike Özçelik, Devrim Çabuk, Ayşe Gökdurnalı, Özlem Balvan, Yaşar Yıldız, Metin Şeker, Nuriye Özdemir, Burcu Yapar, Özgür Tanrıverdi, Yusuf Günaydin, Serkan Menekşe, Berna Öksüzoğlu, Asude Aksoy, Bülent Erdoğan, M. Bekir Hacıoglu, Erkan Arpaci, Alper Sevinç, Mehmet Atilla Uysal, Sinem İliaz |
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Přispěvatelé: | Sivas Cumhuriyet Üniversitesi, [Cicin, Irfan -- Turkmen, Esma -- Erdogan, Bulent -- Hacioglu, M. Bekir] Trakya Univ, Sch Med, Dept Med Oncol, Edirne, Turkey -- [Ozatli, Tahsin -- Gokdurnali, Ayse -- Oksuzoglu, Berna] Ankara Dr Abdurrahman Yurtaslan Oncol Training &, Dept Med Oncol, Ankara, Turkey -- [Ozturk, Turkan] Karadeniz Tech Univ, Dept Med Oncol, Sch Med, Trabzon, Turkey -- [Ozcelik, Melike -- Balvan, Ozlem] Dr Lutfi Kirdar Res & Training Hosp, Dept Med Oncol, Istanbul, Turkey -- [Cabuk, Devrim] Kocaeli Univ, Sch Med, Dept Med Oncol, Kocaeli, Turkey -- [Yildiz, Yasar] Ataturk Training & Res Hosp, Dept Med Oncol, Izmir, Turkey -- [Seker, Metin] Cumhuriyet Univ, Dept Med Oncol, Sch Med, Sivas, Turkey -- [Ozdemir, Nuriye] Ankara Numune Training & Res Hosp, Dept Med Oncol, Ankara, Turkey -- [Yapar, Burcu] Pamukkale Univ, Dept Med Oncol, Sch Med, Denizli, Turkey -- [Tanriverdi, Ozgur] Mugla Univ, Dept Med Oncol, Sch Med, Mugla, Turkey -- [Gunaydin, Yusuf] Gazi Univ, Dept Med Oncol, Sch Med, Ankara, Turkey -- [Menekse, Serkan] Celal Bayar Univ, Dept Med Oncol, Sch Med, Manisa, Turkey -- [Aksoy, Asude] Inonu Univ, Dept Med Oncol, Sch Med, Malatya, Turkey -- [Arpaci, Erkan] Sakarya Res & Training Hosp, Dept Med Oncol, Sakarya, Turkey -- [Sevinc, Alper] Gaziantep Univ, Dept Med Oncol, Sch Med, Gaziantep, Turkey, aksoy, asude -- 0000-0002-5609-9658, MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tanrıverdi, Özgür |
Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Oncology predictive factors endocrine system diseases medicine.medical_treatment retrospective study platinum complex lcsh:Medicine medical record review pelvis lymph node Turkey (republic) chemoradiotherapy 0302 clinical medicine Carcinosarcoma Stage (cooking) Lymph node antineoplastic agent Cerrahi Carcinosarcoma ovary uterine predictive factors prognostic factors cancer adjuvant therapy Standard treatment adult ovary cancer uterine General Medicine ovarian carcinosarcoma female genital diseases and pregnancy complications uterus cancer Serous fluid Uterine aged medicine.anatomical_structure female 030220 oncology & carcinogenesis Original Article adjuvant radiotherapy Predictive factors medicine.medical_specialty overall survival brachytherapy tumor localization carcinosarcoma lymph node dissection paraaortic lymph node ovary prognostic factors Prognostic factors clinical observation uterine carcinosarcoma cancer prognosis Article 03 medical and health sciences Internal medicine medicine cross-sectional study controlled study human survival time Chemotherapy business.industry cancer staging lcsh:R Ovary prediction medicine.disease cancer classification major clinical study Radiation therapy drug efficacy 030104 developmental biology age minimal residual disease business Clear cell |
Zdroj: | Balkan Medical Journal, Vol 33, Iss 5, Pp 517-524 (2016) Volume: 33, Issue: 5 517-524 Balkan Medical Journal |
ISSN: | 0003-8474 2146-3123 |
Popis: | WOS: 000384744100006 PubMed ID: 27761279 Background: Prognostic factors and the standard treatment approach for gynaecological carcinosarcomas have not yet been clearly defined. Although carcinosarcomas are more aggressive than pure epithelial tumours, they are treated similarly. Serous/clear cell and endometrioid components may be predictive factors for the efficacy of adjuvant chemotherapy (CT) or radiotherapy (RT) or RT in patients with uterine and ovarian carcinosarcomas. Heterologous carcinosarcomas may benefit more from adjuvant CT. Aims: We aimed to define the prognostic and predictive factors associated with treatment options in ovarian (OCS) and uterine carcinosarcoma (UCS). Study Design: Retrospective cross-sectional study Methods: We retrospectively reviewed the medical records of patients with ovarian and uterine carcinosarcoma from 2000 to 2013, and 127 women were included in this study (24 ovarian and 103 uterine). Patients admitted to seventeen oncology centres in Turkey between 2000 and December 2013 with a histologically proven diagnosis of uterine carcinosarcoma with FIGO 2009 stage I-III and patients with sufficient data obtained from well-kept medical records were included in this study. Stage IV tumours were excluded. The patient records were retrospectively reviewed. Data from 104 patients were evaluated for this study. Results: Age (>= 70 years) was a poor prognostic factor for UCS (p=0.036). Pelvic +/- para aortic lymph node dissection did not affect overall survival (OS) (p=0.35). Macroscopic residual disease was related with OS (p |
Databáze: | OpenAIRE |
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