Soluble CD4, CD8, and HLA molecules in commercial immunoglobulin preparations

Autor:	U. Westhoff, H. Grosse-Wilde, Rainer Blasczyk
Rok vydání:	1993
Předmět:	chemistry.chemical_classification biology medicine.drug_class CD8 Antigens Immunoglobulins Intravenous General Medicine Human leukocyte antigen Immunostimulant Molecular biology Enzyme Immune system chemistry Biochemistry Antigen Solubility HLA Antigens Immunopathology CD4 Antigens biology.protein medicine Humans Antibody CD8
Zdroj:	Lancet (London, England). 341(8848)
ISSN:	0140-6736
Popis:	CD4 and CD8 exist in membrane-bound and soluble forms. These antigens are the physiological ligands for molecules of HLA classes I and II, which we have found in soluble form in commercial immunoglobulin preparations. We measured concentrations of soluble CD4 and CD8, as well as soluble HLA-ABC and HLA-RQP in sixteen immunoglobulin preparations by enzyme immunosorbent assays. Only two preparations contained detectable CD8, and nine had soluble CD4 in varying amounts. There was great variation in concentrations of soluble HLA molecules. It is possible that the immunomodulating effects of immunoglobulin therapy in disorders with immune aetiology are due, at least partly, to these contaminating molecules.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7840cdb3f0fbfe79af6c26f1699b72bc https://pubmed.ncbi.nlm.nih.gov/8099659 Zobrazit plný text záznamu Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.