A 30-day toxicity study of inhaled fenitrothion in the albino rat
| Autor: | M. Pesant, D.J. Ecobichon, C. Breckenridge, H.D. Durham |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Urinary system Normal values Motor Activity Toxicology Fenitrothion Fasciculation Eating chemistry.chemical_compound Sex Factors Internal medicine medicine Animals Cholinesterases Cholinesterase Pharmacology Inhalation biology Chemistry Rats Inbred Strains Liter Rats Endocrinology Toxicity Acetylcholinesterase biology.protein Female medicine.symptom Carboxylic Ester Hydrolases |
| Zdroj: | Toxicology and Applied Pharmacology. 62:32-43 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(82)90099-0 |
| Popis: | The significance of inhalation as a route of exposure to organophosphorus insecticides was assessed by exposing male and female Sprague-Dawley rats via a nose-only technique to respirable (2.0-μm diameter), aqueous aerosols of a fenitrothion-emulsifier mixture (11% technical fenitrothion, 1.5% Atlox 3409F, 1.5% Dowanol TPM, 86% water) at chamber concentrations of 6.7, 20.0, and 60.0 μg insecticide/liter of air for 2 hr/day for 30 consecutive days. Rats of each treatment group were bled at Days 8 and 15, and at necropsy after 30 days of treatment. Subgroups (six rats/sex/treatment) were necropsied 30 days post-treatment to study the regression of treatment effects. Measured parameters included body weight, food consumption, plasma, and erythrocyte cholinesterase as well as brain cholinesterase and hepatic and renal carboxylesterases of necropsied animals. Body weight and food intake were depressed in all groups including air-exposed control rats. Muscle fasciculations (♀, high dose) and a clear secretion (♂ and ♀, high dose) were correlated with a dose-dependent plasma, erythrocyte, and brain cholinesterase inhibition which was greater after 15 and 30 days of treatment than after 7 days. Brain, plasma, and erythrocyte enzyme levels had returned to normal values by 30 days post-treatment, as had the hepatic and renal carboxylesterases. Detailed hematological, urinary, blood biochemical, and histopathological studies revealed no other deleterious effects of treatment. |
| Databáze: | OpenAIRE |
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