Intraocular pressure following phacoemulsification in patients with and without exfoliation syndrome: a 2 year prospective study
| Autor: | Andrew Merkur, George Mintsioulis, N.G. Ziakas, William Hodge, A. G. P. Konstas, Y.I. Pan, J. M. Liebmann, S. Giannikakis, Robert Ritch, Karim F. Damji |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Intraocular pressure genetic structures Eye disease medicine.medical_treatment Glaucoma Exfoliation Syndrome Cataract Exfoliation syndrome Cellular and Molecular Neuroscience Ophthalmology medicine Humans In patient Postoperative Period Prospective Studies Prospective cohort study Intraocular Pressure Aged Aged 80 and over Phacoemulsification business.industry Clinical Science - Extended Report Middle Aged medicine.disease eye diseases Sensory Systems Female sense organs business Cohort study Follow-Up Studies |
| Zdroj: | The British journal of ophthalmology. 90(8) |
| ISSN: | 0007-1161 |
| Popis: | Aim: To determine the long term intraocular pressure (IOP) response to phacoemulsification in patients with and without exfoliation syndrome (XFS). Methods: Prospective, multicentre, cohort study with the following inclusion criteria: age over 50 years, open iridocorneal angle, and cataract. Two groups were enrolled: those with XFS and those without. The main outcome was mean IOP reduction 2 years after phacoemulsification cataract extraction (PCE). Univariate and multivariate analyses were performed. Results: 183 patients were enrolled, 71 with and 112 without XFS. There were 29 patients with glaucoma in both groups. Mean baseline IOP was higher in XFS compared to control eyes (17.60 (SD 3.23) mm Hg v 16.08 (3.18) mm Hg, p = 0.002). Overall IOP reduction was significantly greater in the XFS group at the 2 year time point (−1.85 mm Hg v −0.62 mm Hg in the controls (p = 0.0037)). Multivariate analysis demonstrated that the IOP lowering effect in the XFS group may be related to irrigation volume at the time of surgery. In the subgroup analyses IOP lowering was significantly greater in the XFS and XFG patients than in controls without glaucoma, and POAG controls, respectively. The percentage of patients with a postoperative IOP spike was similar and relatively high in both XFS and control groups (34% v 25%; p = 0.54). Conclusion: IOP decreases more in patients with XFS following PCE compared to control eyes without XFS. This effect is more pronounced in glaucoma patients and persists for at least 2 years. |
| Databáze: | OpenAIRE |
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