Modified Therapeutic Antibodies: Improving Efficacy
Autor: | Xiang-Min Yang, Zhi-Nan Chen, Xue-Qin Zhang, Ji-Min Dai, Jingyao Dai |
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Rok vydání: | 2021 |
Předmět: |
Bispecific antibody
Environmental Engineering Efficacy General Computer Science biology business.industry Materials Science (miscellaneous) General Chemical Engineering General Engineering Energy Engineering and Power Technology Modification Single chain Engineering (General). Civil engineering (General) Chimeric antigen receptor Therapeutic antibody Antigen Cancer research biology.protein Medicine TA1-2040 Effector functions Antibody business Antibody–drug conjugate |
Zdroj: | Engineering, Vol 7, Iss 11, Pp 1529-1540 (2021) |
ISSN: | 2095-8099 |
Popis: | The prosperity of the biotherapeutics market reflects the feasibility and effectiveness of therapeutic antibodies for the treatment of cancers, inflammatory disorders, and refractory infections. As drawbacks emerge in clinical trials and practice, such as impeded binding, reduced effector functions, and frequent adverse reactions, modifications of therapeutic antibodies are unprecedently burgeoning in research and development (R&D). These modifications include: ① modified glycosylation; ② fragment of crystallizable domain (Fc) amino acid alterations; ③ cross-isotype or cross-subclass exchanges; ④ antibody–drug conjugates (ADCs); ⑤ single chain of variable region fragment (scFv) for chimeric antigen receptor T (CAR-T) cells; and ⑥ bispecific antibodies (bsAbs) in order to promote binding affinity, half-life in circulation, effectiveness toward target cells and, ultimately, to achieve overall improved efficacy. While many achievements have been made around the world in the past decades, China has been playing an active role in this realm, with its great demand for biotherapeutics with R&D potential. This review recapitulates the international progress that has been achieved with modified therapeutic antibodies, and then focuses on that of China in an independent section. |
Databáze: | OpenAIRE |
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