Glycotherapy: New Advances Inspire a Reemergence of Glycans in Medicine
Autor: | Jason E. Hudak, Carolyn R. Bertozzi |
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Rok vydání: | 2014 |
Předmět: |
Modern medicine
Glycan Clinical Biochemistry Nanotechnology 01 natural sciences Biochemistry Article 03 medical and health sciences Polysaccharides Drug Discovery Humans Molecular Biology 030304 developmental biology Pharmacology 0303 health sciences biology 010405 organic chemistry General Medicine 0104 chemical sciences 3. Good health carbohydrates (lipids) Biopharmaceutical biology.protein Medicine Molecular Medicine Engineering ethics |
Zdroj: | Chemistry & Biology. 21(1):16-37 |
ISSN: | 1074-5521 |
DOI: | 10.1016/j.chembiol.2013.09.010 |
Popis: | The beginning of the 20(th) century marked the dawn of modern medicine with glycan-based therapies at the forefront. However, glycans quickly became overshadowed as DNA- and protein-focused treatments became readily accessible. The recent development of new tools and techniques to study and produce structurally defined carbohydrates has spurred renewed interest in the therapeutic applications of glycans. This review focuses on advances within the past decade that are bringing glycan-based treatments back to the forefront of medicine and the technologies that are driving these efforts. These include the use of glycans themselves as therapeutic molecules as well as engineering protein and cell surface glycans to suit clinical applications. Glycan therapeutics offer a rich and promising frontier for developments in the academic, biopharmaceutical, and medical fields. |
Databáze: | OpenAIRE |
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