Effect of Megestrol Acetate and Testosterone on Body Composition and Hormonal Responses in COPD Cachexia
| Autor: | Edwardo Torres, Richard Casaburi, Janos Porszasz, Junko Nakata, Mehdi Rambod, Lawrence Bistrong |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Chronic Obstructive Pulmonary Disease medicine.medical_treatment Clinical Trials and Supportive Activities cachexia Gastroenterology Cachexia megesterol Clinical Research Weight loss Internal medicine medicine Obesity Lung Original Research Nutrition body composition business.industry Prevention Evaluation of treatments and therapeutic interventions medicine.disease 6.1 Pharmaceuticals Megestrol acetate testosterone Respiratory Lean body mass medicine.symptom Underweight business Body mass index Weight gain Anabolic steroid medicine.drug |
| Zdroj: | Chronic obstructive pulmonary diseases (Miami, Fla.), vol 3, iss 1 |
| ISSN: | 2372-952X |
| Popis: | Background: Underweight chronic obstructive pulmonary disease (COPD) patients with involuntary weight loss have a poor prognosis; no effective therapy is currently available. We conducted the first clinical trial seeking to determine whether combination therapy with an appetite stimulant and an anabolic steroid would have beneficial effects on body composition for patients with COPD cachexia. Methods: We conducted a 12–week pilot study in which 4 men and 5 women (age 64±10 y, forced expiratory volume in 1 second [FEV1] 31±9 %pred., body mass index [BMI] 18±3 kg/m2) with low-normal testosterone levels (average 532±45ng/dl in men and 12.4±5.3ng/dl in women) and weight loss ≥10 lbs over the previous year were treated with oral megestrol acetate 800mg/day plus weekly testosterone enanthate injections, initially 125 mg in men and 40 mg in women, with doses subsequently adjusted targeting circulating nadir testosterone levels of 850 and 300 ng/dl, respectively. Results: On treatment, nadir testosterone level increases averaged 160±250 ng/dl (NS) in men and 322±49 (p |
| Databáze: | OpenAIRE |
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