Osteoporosis in chronic obstructive pulmonary disease
| Autor: | Emiel F.M. Wouters, Elisabeth A. P. M. Romme, Erica P.A. Rutten, Frank W J M Smeenk |
|---|---|
| Přispěvatelé: | Pulmonologie, RS: CAPHRI School for Public Health and Primary Care, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting |
| Rok vydání: | 2013 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Bone density Osteoporosis Disease Systemic inflammation vitamin D deficiency Pulmonary Disease Chronic Obstructive Adrenal Cortex Hormones Risk Factors Internal medicine medicine Vitamin D and neurology Prevalence Immunology and Allergy Animals Humans Inflammation COPD business.industry Smoking Public Health Environmental and Occupational Health Age Factors medicine.disease Prognosis Vitamin D Deficiency Pathophysiology respiratory tract diseases Physical therapy medicine.symptom business |
| Zdroj: | Expert Review of Respiratory Medicine, 7(4), 397-410. Routledge/Taylor & Francis Group |
| ISSN: | 1747-6356 1747-6348 |
| Popis: | Chronic obstructive pulmonary disease (COPD) is being regarded as a heterogeneous disease with clinically significant pulmonary and extrapulmonary manifestations, such as emphysema, cardiovascular disease and osteoporosis. Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and, consequently, an increased risk of fracture. Fractures resulting from osteoporosis might contribute to increased morbidity and mortality, particularly in COPD patients. The high prevalence of osteoporosis in COPD patients is assumed to be due to common risk factors, such as older age and tobacco smoking, and COPD-specific risk factors, such as systemic inflammation, vitamin D deficiency and the use of oral or inhaled corticosteroids. This review provides a state-of-the-art summary of the prevalence, pathophysiology, diagnosis, risk factors and treatment of osteoporosis in COPD patients. It also discusses potential mechanisms linking COPD with osteoporosis. |
| Databáze: | OpenAIRE |
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