Stress-induced alterations of social behavior are reversible by antagonism of steroid hormones in C57/BL6 mice
| Autor: | Benedikt Andreas Gasser, Markus G. Mohaupt, Walter Senn, Johann Kurz, Geneviève Escher |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class medicine.medical_treatment Chronic swim test 610 Medicine & health chemistry.chemical_compound Receptors Glucocorticoid Internal medicine Animals Hypnotics and Sedatives Medicine Etomidate Cyproterone Acetate Social Behavior C57BL/6 mice Mineralocorticoid Receptor Antagonists Steroid hormones Pharmacology Behavior Animal business.industry Cyproterone acetate Androgen Antagonists General Medicine Androgen Hormones Metformin Mice Inbred C57BL Steroid hormone Stress induction Endocrinology chemistry Mineralocorticoid Potassium canrenoate Female Original Article Canrenoic Acid business CRH (corticotropin-releasing hormone)–ACTH (adrenocorticotropic hormone) Stress Psychological Homeostasis Glucocorticoid medicine.drug Hormone |
| Zdroj: | Gasser, Benedikt Andreas; Kurz, Johann; Senn, Walter; Escher, Genevieve; Mohaupt, Markus Georg (2021). Stress-induced alterations of social behavior are reversible by antagonism of steroid hormones in C57/BL6 mice. Naunyn-Schmiedeberg's archives of pharmacology, 394(1), pp. 127-135. Springer 10.1007/s00210-020-01970-7 Naunyn-Schmiedeberg's Archives of Pharmacology |
| ISSN: | 1432-1912 0028-1298 |
| Popis: | Various disturbances of social behavior, such as autism, depression, or posttraumatic stress disorder, have been associated with an altered steroid hormone homeostasis and a dysregulation of the hypothalamus–pituitary–adrenal axis. A link between steroid hormone antagonists and the treatment of stress-related conditions has been suggested. We evaluated the effects of stress induction on social behavior in the three chambers and its potential reversibility upon specific steroid hormone antagonism in mice. C57BL/6 mice were stressed twice daily for 8 days by chronic swim testing. Social behavior was evaluated by measuring, first, the preference for sociability and, second, the preference for social novelty in the three-chamber approach before and after the chronic swim test. The reversibility of behavior upon stress induction was analyzed after applying steroid hormone antagonists targeting glucocorticoids with etomidate, mineralocorticoids with potassium canrenoate, and androgens with cyproterone acetate and metformin. In the chronic swim test, increased floating time from 0.8 ± 0.2 min up to 4.8 ± 0.25 min was detected (p |
| Databáze: | OpenAIRE |
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