Meta-analytic evidence for increased low-grade systemic inflammation and oxidative stress in hypothyroid patients. Can levothyroxine replacement therapy mitigate the burden?
| Autor: | Mariana Lorena Tellechea |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Hormone Replacement Therapy Endocrinology Diabetes and Metabolism Levothyroxine 030209 endocrinology & metabolism Systemic inflammation medicine.disease_cause Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Hypothyroidism Internal medicine Diabetes mellitus medicine Humans Subclinical infection Inflammation biology business.industry C-reactive protein medicine.disease Malondialdehyde Oxidative Stress Thyroxine chemistry 030220 oncology & carcinogenesis Meta-analysis biology.protein medicine.symptom business Oxidative stress medicine.drug |
| Zdroj: | Endocrine. 72(1) |
| ISSN: | 1559-0100 |
| Popis: | This series of meta-analyses were aimed to elucidate the impact of hypothyroidism on low-grade systemic inflammation and oxidative stress assessed by C-reactive protein (CRP) and malondialdehyde (MDA) respectively; and to evaluate the effect of levothyroxine replacement therapy (LRT) on those outcomes. PubMed database and the key studies references were searched prior to March 3, 2020. Data on serum or plasma CRP and MDA levels in SHT (subclinical) and/or OHT (overt) hypothyroid patients and controls were extracted to compute overall standardized mean differences (SMD) by the random-effects model. A total of 93 studies were entered into analyses and ten main meta-analyses were performed. OHT (SMD = 0.72 [0.39; 1.04], k = 35), SHT (SMD = 1.58 [0.78; 2.38], k = 56) and even mild SHT (TSH |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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