Gender Issues in the Pharmacotherapy of Opioid-Addicted Women: Buprenorphine
| Autor: | Gabriele Fischer, Annemarie Unger, Erika Jung, Bernadette Winklbaur |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Narcotic Antagonists media_common.quotation_subject Breastfeeding Medicine (miscellaneous) Special needs Article Sex Factors Pharmacotherapy Pregnancy Epidemiology medicine Humans Women Psychiatry Randomized Controlled Trials as Topic media_common business.industry Infant Newborn Pregnancy Outcome General Medicine Abstinence Opioid-Related Disorders medicine.disease Mental health Buprenorphine Pregnancy Complications Substance abuse Psychiatry and Mental health Clinical Psychology Treatment Outcome Female business Neonatal Abstinence Syndrome medicine.drug |
| Zdroj: | Journal of Addictive Diseases. 29:217-230 |
| ISSN: | 1545-0848 1055-0887 |
| Popis: | Gender, a biological determinant of mental health and illness, plays a critical role in determining patients’ susceptibility, exposure to mental health risks, and related outcomes. Regarding sex differences in the epidemiology of opioid dependence, one third of the patients are women of childbearing age. Women have an earlier age of initiation of substance use and a more rapid progression to drug involvement and dependence than men. Generally few studies exist which focus on the special needs of women in opioid maintenance therapy. The aim of this paper is to provide an overview of treatment options for opioid-dependent women, with a special focus on buprenorphine, and to look at recent findings related to other factors that should be taken into consideration in optimizing the treatment of opioid-dependent women. Issues addressed include the role of gender in the choice of medication assisted treatment, sex differences in pharmacodynamics and pharmacokinetics of buprenorphine drug interactions, cardiac interactions, induction of buprenorphine in pregnant patients, the neonatal abstinence syndrome and breastfeeding. This paper aims to heighten the awareness for the need to take gender into consideration when making treatment decisions in an effort to optimize services and enhance the quality of life of women suffering from substance abuse. |
| Databáze: | OpenAIRE |
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