Natural killer cells activated by MHC class I(low) targets prime dendritic cells to induce protective CD8 T cell responses
| Autor: | Anja Bubeck, Heidi Braumüller, Ulrich H. Koszinowski, Alain Gumy, Uwe Reusch, Gert Riethmüller, Oliver Egeter, Ralph Mocikat, Jacques A. Louis, Heike Ziegler, Reinhard Mailhammer, Martin Röcken |
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| Rok vydání: | 2003 |
| Předmět: |
Lymphoma
T cell Immunology Antigen presentation CD1 chemical and pharmacologic phenomena CD8-Positive T-Lymphocytes Mice Neoplasms MHC class I medicine Immunology and Allergy Cytotoxic T cell Animals Antigen-presenting cell biology Carcinoma Histocompatibility Antigens Class I Dendritic Cells Natural killer T cell Killer Cells Natural Infectious Diseases medicine.anatomical_structure biology.protein CD8 |
| Zdroj: | Immunity. 19(4) |
| ISSN: | 1074-7613 |
| Popis: | Conserved molecular patterns derived from pathogenic microorganisms prime antigen-presenting dendritic cells (DC) to induce adaptive T cell responses. In contrast, virus-infected or tumor cells that express low levels of major histocompatibility complex (MHC) class I activate natural killer (NK) cells for direct killing. It is unknown whether NK cell recognition of MHC class Ilow targets can also induce adaptive T cell responses. Here, we show that MHC class Ilow targets initiate a cascade of immune responses, starting with the immediate activation of NK cells. The activated NK cells then prime DC to produce IL-12 and to induce highly protective CD8 T cell memory responses. Therefore, sensing of MHC class Ilow targets by NK cells can link innate and adaptive immunity to induce protective T cell responses and may alarm the immune system during early infection with noncytopathic viruses. |
| Databáze: | OpenAIRE |
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