Studies on possible mechanisms of action of electroconvulsive therapy; effects of repeated electrically induced seizures on rat brain receptors for monoamines and other neurotransmitters
| Autor: | Frank Owen, J. F. Deakin, M. J. Dashwood, Alan J. Cross |
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| Rok vydání: | 1981 |
| Předmět: |
Serotonin
medicine.medical_specialty Receptors Dopamine Levodopa Norepinephrine chemistry.chemical_compound Dopamine Internal medicine medicine Animals Electroconvulsive Therapy Receptor gamma-Aminobutyric Acid 5-HT receptor Brain Chemistry Pharmacology Ligand (biochemistry) Rats Receptors Neurotransmitter Endocrinology Monoamine neurotransmitter chemistry Dihydroalprenolol Tranylcypromine medicine.drug |
| Zdroj: | Psychopharmacology. 73:345-349 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/bf00426463 |
| Popis: | There is evidence that repeated electroconvulsive shocks (ECS) in rats potentiate dopamine (DA)-, serotonin (5HT)- and alpha-noradrenergic (alpha-NA)-mediated drug-induced behaviour and reduce opiate-induced behaviours. These studies suggest changes at the level of the receptor or beyond. However, high affinity in vitro 3H-ligand binding studies in brain membranes from ECS-treated control rats failed to demonstrate generalized ECS-induced changes in 5HT, DA, alpha-NA or opiate receptor binding. Binding of the beta-receptor ligand dihydroalprenolol (3H-DHA) was significantly reduced in ECS-treated rat brain membranes. This may be secondary to effects on NA neurones since ECS-induced reduction of 3H-DHA binding did not occur in animals with 6-hydroxydopamine-induced depletion of cortical noradrenaline. In conjunction with other studies, the results suggest that electroconvulsive therapy may have a noradrenergic mechanism of action. |
| Databáze: | OpenAIRE |
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