Evaluation of the association between plasma concentration of N-terminal proatrial natriuretic peptide and outcome in cats with cardiomyopathy
| Autor: | Tanja M. Zimmering, D. Simon, Felix Meneses, Ingo Nolte, Stephan Hungerbühler |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Cardiomyopathy Cat Diseases Internal medicine Blood plasma Natriuretic peptide Animals Medicine Protein Precursors N-terminal proatrial natriuretic peptide Heart Failure CATS General Veterinary business.industry medicine.disease Endocrinology Case-Control Studies Heart failure Plasma concentration Cats Female Cardiomyopathies business Atrial Natriuretic Factor Biomarkers |
| Zdroj: | Journal of the American Veterinary Medical Association. 237:665-672 |
| ISSN: | 0003-1488 |
| DOI: | 10.2460/javma.237.6.665 |
| Popis: | Objective—To determine whether plasma N-terminal proatrial natriuretic peptide (NT-proANP) concentration could predict the outcome (survival duration) of cats with cardiomyopathy (CM). Design—Case-control study. Animals—51 cats with CM (25 with and 26 without congestive heart failure [CHF]) and 17 healthy cats. Procedures—Cats were thoroughly examined and assigned to 1 of 3 groups (control, CM with CHF, and CM alone). Plasma NT-proANP concentrations were measured by use of a human proANP(1-98) ELISA. Survival durations were compared between CM groups. Results—Plasma NT-proANP concentrations differed significantly among the 3 groups, and survival durations differed significantly between the 2 CM groups. Median (range) NT-proANP concentration was 413 fmol/mL (52 to 940 fmol/mL) in the control group, 1,254 fmol/mL (167 to 2,818 fmol/mL) in the CM alone group, and 3,208 fmol/mL (1,189 to 15,462 fmol/mL) in the CM with CHF group. At a cutoff of 517 fmol/mL, NT-proANP concentration had a sensitivity of 90% and specificity of 82% for detecting CM. Multivariate analysis revealed that only the variable left atrium-to-aortic diameter ratio was a significant predictor of survival duration. Conclusions and Clinical Relevance—Plasma NT-proANP concentration may have potential as a testing marker for distinguishing healthy cats from cats with CM. It may also be useful for distinguishing CM cats with CHF from those without CHF The value of NT-proANP concentration as a predictor of survival duration was not supported in this study and requires further evaluation. (J Am Vet Med Assoc 2010;237:665-672) |
| Databáze: | OpenAIRE |
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