SALIVARY TESTOSTERONE LEVELS AND THE PROGRESS OF PUBERTY IN THE NORMAL BOY
| Autor: | D. Riad-Fahmy, R. V. Walker, R. F. Walker, P. Teague, Gary Butler, S G Ratcliffe |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
Aging Periodicity medicine.medical_specialty Saliva Adolescent Endocrinology Diabetes and Metabolism Clinical onset Pubertal stage Endocrinology Rhythm Reference Values Internal medicine Testis Humans Medicine Testosterone Sex organ Circadian rhythm Child business.industry Puberty Salivary testosterone Pubic hair Circadian Rhythm medicine.anatomical_structure Data Interpretation Statistical business |
| Zdroj: | Clinical Endocrinology. 30:587-596 |
| ISSN: | 1365-2265 0300-0664 |
| DOI: | 10.1111/j.1365-2265.1989.tb01431.x |
| Popis: | SUMMARY Salivary testosterone (ST) levels were measured in 84 boys aged 7.3–16.2 from the Edinburgh Growth Study. The correlation coefficient between matched plasma/saliva samples was 0.88. Six samples were collected over the course of one day from 0900 to 2100 h each month in the majority of the children for 4 consecutive months. Mean daily ST levels showed a significant rise between each pubertal stage (genital (G) and pubic hair (PH)). The rise in ST became more rapid once a mean testicular volume (MTV) of 10 ml had been reached. The diurnal rhythm was assessed by individual curve fitting on the log scale and by cosinor analysis. A rhythm was present prepubertally and developed into a pattern similar to that of the adult rhythm by stage G3. The monthly rate of rise of ST was greatest at stage G4. A significant rise in ST levels was detectable immediately prior to an increase in MTV to 3 ml. This allowed earlier recognition of the clinical onset of puberty at testicular volume of 3 ml, which in this group occurred at 10.9 (SD 0.9) years. ST is a non-invasive and sensitive method for the serial monitoring of gonadal function in the prepubertal and adolescent boy. |
| Databáze: | OpenAIRE |
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