Immune Microenvironment in Sporadic Early-Onset versus Average-Onset Colorectal Cancer

Autor:	Fanny Andric, Ala Al-Fairouzi, Yvonne Wettergren, Louis Szeponik, Elinor Bexe-Lindskog, James C. Cusack, Gerald Tumusiime, Marianne Quiding-Järbrink, David Ljungman
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Cancer Research Oncology tumor-infiltrating lymphocytes gene expression tumor microenvironment early-onset colorectal cancer immunofluorescence
Zdroj:	Cancers Volume 15 Issue 5 Pages: 1457
ISSN:	2072-6694
DOI:	10.3390/cancers15051457
Popis:	The incidence of left-sided colon and rectal cancer in young people are increasing worldwide, but its causes are poorly understood. It is not clear if the tumor microenvironment is dependent on age of onset, and little is known about the composition of tumor-infiltrating T cells in early-onset colorectal cancer (EOCRC). To address this, we investigated T-cell subsets and performed gene expression immune profiling in sporadic EOCRC tumors and matched average-onset colorectal cancer (AOCRC) tumors. Left-sided colon and rectal tumors from 40 cases were analyzed; 20 EOCRC (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7833bd7499e656655d948f2dfb30e578 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.