High Rate of Twins among Offspring of Mothers with the Järvi-Hakola-Nasu Disease and with Comments on Disorders Associated with Twinning
| Autor: | A. W. Eriksson, H. P. A. Hakola |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Lipodystrophy Offspring media_common.quotation_subject Twins Disease Pregnancy Internal medicine medicine Humans Birth Rate Ovulation Finland Genetics (clinical) media_common High rate business.industry Incidence (epidemiology) Confidence interval Pregnancy Complications Endocrinology Dementia Female Pregnancy Multiple Nasu disease Crystal twinning business |
| Zdroj: | Acta geneticae medicae et gemellologiae: twin research. 46:37-46 |
| ISSN: | 2059-6324 0001-5660 |
| DOI: | 10.1017/s0001566000000738 |
| Popis: | Finnish mothers with Järvi-Hakola-Nasu disease, progressive dementia with lipomembranous polycystic osteodysplasia (McKusick 221770) have a high rate of twin maternities, 128.2/1000. The exact 99% confidence intervals are 28.7 – 322.2/1000, thus above the average twinning rate in Finland, i.e. 15/1000. This eightfold increase in twinning may be an indication of a disturbed cortico-hypothalmic-hypophyseal axis or an other premorbid hormonal imbalance. It is concluded that even if dizygotic twinning is as a rule an event in itself, not only iatrogenic factors, as ovulation inducers, etc., but also some genetic disorders may be associated with twinning. More studies are needed to elucidate the incidence of twinning in families with these disorders. |
| Databáze: | OpenAIRE |
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