| Autor: |
Cédric Dananché, Gláucia Paranhos-Baccalà, Mélina Messaoudi, Mariam Sylla, Shally Awasthi, Ashish Bavdekar, Jean-William Pape, Vanessa Rouzier, Jianwei Wang, Sonali Sanghavi, Souleymane Diallo, Monidarin Chou, Tekchheng Eap, Mala Rakoto-Andrianarivelo, Hubert Endtz, Lili Ren, Budragchaagiin Dash-Yandag, Rosa Guillen, Pagbajabyn Nymadawa, Graciela Russomando, Florence Komurian-Pradel, Philippe Vanhems, Valentina Sánchez Picot |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Am J Trop Med Hyg |
| Popis: |
The role of microbial coinfection in the pathogenesis of pneumonia in children is not well known. The aim of this work was to describe the prevalence of microorganism co-detection in nasopharyngeal samples (NPS) of pneumonia cases and control subjects and to study the potential association between nasopharyngeal microorganism co-detection and pneumonia. A case-control study was carried out from 2010 to 2014 in nine study sites located in low- or middle-income countries. The data from 888 children under 5 years of age with pneumonia (cases) and 870 children under 5 without pneumonia (controls) were analyzed. Nasopharyngeal samples were collected; reverse transcription polymerase chain reaction (RT-PCR) enabled the detection of five bacteria and 19 viruses. Multiple, mixed-effects logistic regression modeling was undertaken to evaluate the association between microorganism co-detection and pneumonia. A single Streptococcus pneumoniae colonization was observed in 15.2% of the controls and 10.1% of the cases (P = 0.001), whereas S. pneumoniae and a single virus co-detection was observed in 33.3% of the cases and in 14.6% of the controls (P P P = 0.13). This study suggests that coinfection of S. pneumoniae and certain viruses may play a role in the pathophysiology of pneumonia in children. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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