INFLUENCE OF QUINAPRIL ON THE REGULATORY-ADAPTIVE STATUS OF PATIENTS WITH CHRONIC HEART FAILURE HYHA CLASS I: RESULTS OF NOT COMPARATIVE STUDY
| Autor: | S. G. Kanorskiy, V. M. Pokrovskiy, V. G. Tregubov |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
сердечно-дыхательный синхронизм lcsh:Diseases of the circulatory (Cardiovascular) system Ambulatory blood pressure Prohormone regulatory-adaptive status RM1-950 хроническая сердечная недостаточность регуляторно-адаптивный статус Internal medicine cardio-respiratory synchronism medicine Diseases of the circulatory (Cardiovascular) system Pharmacology (medical) Treadmill business.industry lcsh:RM1-950 VO2 max Cardiorespiratory fitness medicine.disease Brain natriuretic peptide квинаприл chronic heart failure Endocrinology lcsh:Therapeutics. Pharmacology Quinapril quinapril lcsh:RC666-701 Heart failure RC666-701 Cardiology Therapeutics. Pharmacology Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 8, Iss 4, Pp 526-530 (2015) |
| ISSN: | 2225-3653 1819-6446 |
| Popis: | Aim. To assess effects of quinapril on the regulatory-adaptive status (RAS) in patients with chronic heart failure (CHF) NYHA class 1 and arterial hypertension (HT). Material and methods. Patients (n=49) with CHF NYHA class I and HT stage I–II (25 men and 24 women, aged 52.5±8.4 years) were included into an open noncomparative study. A cardio-respiratory synchronization (CRS) test, 6 minute walk test, treadmill test with evaluation of the maximal oxygen uptake during exercise, ambulatory blood pressure monitoring, echocardiography , determination of N-terminal prohormone of brain natriuretic peptide (NT-proBNP) plasma level were performed at baseline and after 6 months of quinapril therapy. Results. The quinapril treatment (average daily dose 17.3±7.9 mg) improved myocardium structural and functional parameters, increased the exercise tolerance, reduced neurohumoral activity , improved the RAS according to CRS test: increase in synchronization range of cardiorespiratory cycles per minute from 8.0±2.1 to 11.0±2.5 (Δ27.3%; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|