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Yongjun Han,1,* Runhua Zhang,2,3,* Dandan Yang,4 Dongye Li,5 Hualu Han,6 Huiyu Qiao,6 Shuo Chen,6 Yu Wang,2,3 Miaoxin Yu,2,3 Yin Hong,2,3 Zhiqun Wang,1 Xihai Zhao,6,* Gaifen Liu2,3,* 1Department of Radiology, Aerospace Center Hospital, Beijing, Peopleâs Republic of China; 2Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, Peopleâs Republic of China; 3China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, Peopleâs Republic of China; 4Center for Brain Disorders Research, Capital Medical University and Beijing Institute of Brain Disorders, Beijing, Peopleâs Republic of China; 5Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, Peopleâs Republic of China; 6Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Xihai ZhaoCenter for Biomedical Imaging Research, School of Medicine, Tsinghua University, Haidian District, Beijing, 100084, Peopleâs Republic of ChinaTel +86-10-62792662Fax +86-10-62796175Email xihaizhao@tsinghua.edu.cnGaifen LiuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Fengtai District, Beijing, 100070, Peopleâs Republic of ChinaTel +86-10-59976746Email liugaifen1997@163.comBackground and Purpose: The association between risk factors and intracranial atherosclerosis disease (ICAD) determined by magnetic resonance (MR) vessel wall imaging in Chinese population has not been investigated. The aim of this study was to investigate the associations of conventional vascular risk factors with asymptomatic and symptomatic ICAD using MR vessel wall imaging in Chinese population.Methods: The study population was recruited from two cohort studies of ICASMAP and CAMERA comprised 104 symptomatic ICAD subjects (57.1 ± 11.1 years; 35.6% females), 51 asymptomatic ICAD subjects (70.1 ± 8.4 years; 50.0% females) and 418 controls (58.0 ± 13.3 years; 61.0% females) defined as asymptomatic subjects without ICAD on MR vessel wall imaging. We compared the vascular risk factors between the three groups using a multivariate logistic regression analysis.Results: Compared with controls, there was a significant positive association between age (OR: 1.07, 95% CI: 1.03â 1.10, p < 0.001) and hypertension (OR: 3.03, 95% CI: 1.45â 6.36, p = 0.003) and asymptomatic ICAD. There was a positive association of smoking (OR: 3.41, 95% CI: 1.57â 7.42, p = 0.001), hypertension (OR: 7.43, 95% CI: 3.81â 14.49, p < 0.001) and diabetes (OR: 3.54, 95% CI: 1.93â 6.49, p < 0.001) and an inverse association of high-density lipoprotein (HDL) (p < 0.017) with symptomatic ICAD. Compared to asymptomatic ICAD, there was a significant inverse association of age (OR: 0.86, 95% CI: 0.81â 0.92, p < 0.001) and HDL (p < 0.001) with symptomatic ICAD.Conclusion: Old age and hypertension are associated with asymptomatic ICAD and smoking, hypertension, diabetes and lower HDL are associated with an increased risk of symptomatic ICAD in Chinese population.Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT03417063.Keywords: intracranial artery, atherosclerosis, risk factors, magnetic resonance, vessel wall imaging |
