Cytotoxic steroidal saponins from Ophiopogon japonicus
| Autor: | Yuan Zhou, Ke-Wu Zeng, Jia-Yu Zhang, Ning Li, Yan-Yun Che, Peng-Fei Tu, Liang Zhang |
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| Rok vydání: | 2013 |
| Předmět: |
Magnetic Resonance Spectroscopy
Cell Survival Clinical Biochemistry Ophiopogon japonicus Pharmacology Biochemistry HeLa Inhibitory Concentration 50 Structure-Activity Relationship Endocrinology Humans Cytotoxic T cell Structure–activity relationship Molecular Biology Molecular Structure biology Plant Extracts Chemistry Ophiopogon Organic Chemistry Hep G2 Cells Nuclear magnetic resonance spectroscopy Saponins biology.organism_classification Selective cytotoxicity Antineoplastic Agents Phytogenic Human tumor Plant Tubers Cell culture |
| Zdroj: | Steroids. 78:1-7 |
| ISSN: | 0039-128X |
| DOI: | 10.1016/j.steroids.2012.10.001 |
| Popis: | Four new steroidal saponins, named ophiopogonin P-S (1-4), together with eleven known ones (5-15) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated by spectroscopic and chemical analysis. Compounds 2-15 were evaluated for their cytotoxic activity against five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela). Compounds 2, 5, 6, 8 and 9 were cytotoxic for all cell lines tested. Compounds 7, 11 and 15 showed selective cytotoxicity against some of the cell lines. The structure-activity relationship of these compounds was discussed. |
| Databáze: | OpenAIRE |
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