PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease
| Autor: | Agne Kazlauskaite, Miratul M. K. Muqit |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Parkinson's disease
kinase Ubiquitin-Protein Ligases PINK1 Mitochondrion Bioinformatics Biochemistry Parkin 03 medical and health sciences 0302 clinical medicine Ubiquitin medicine Humans parkin Phosphorylation Protein kinase A Molecular Biology 030304 developmental biology 0303 health sciences biology Neurodegeneration Ubiquitination Parkinson Disease Cell Biology medicine.disease 3. Good health Ubiquitin ligase nervous system diseases Mitochondria State-of-the-Art Review Mutation Nerve Degeneration biology.protein Neuroscience Protein Kinases 030217 neurology & neurosurgery |
| Zdroj: | The Febs Journal |
| ISSN: | 1742-4658 1742-464X |
| Popis: | The discovery of mutations in genes encoding protein kinase PTEN-induced kinase 1 (PINK1) and E3 ubiquitin ligase Parkin in familial Parkinson's disease and their association with mitochondria provides compelling evidence that mitochondrial dysfunction is a major contributor to neurodegeneration in Parkinson's disease. In recent years, tremendous progress has been made in the understanding of how PINK1 and Parkin enzymes are regulated and how they influence downstream mitochondrial signalling processes. We provide a critical overview of the key advances in the field and also discuss the outstanding questions, including novel ways in which this knowledge could be exploited to develop therapies against Parkinson's disease. |
| Databáze: | OpenAIRE |
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