Cyclodextrin‐Calixarene Nanosponges as Potential Platforms for pH‐Dependent Delivery of Tetracycline

Autor:	RM Fontana, Giuseppe Gallo, N Milano, Antonella Di Vincenzo, Lorenzo Barbara, Paolo Lo Meo
Přispěvatelé:	Rosa Maria Fontana, Nicola Milano, Lorenzo Barbara, Antonella Di Vincenzo, Giuseppe Gallo, Paolo Lo Meo
Rok vydání:	2019
Předmět:	chemistry.chemical_classification Nanosponges Cyclodextrin Tetracycline Ph dependent Settore CHIM/06 - Chimica Organica General Chemistry Settore BIO/19 - Microbiologia Generale Combinatorial chemistry chemistry Calixarene Drug delivery medicine medicine.drug
Zdroj:	ChemistrySelect. 4:9743-9747
ISSN:	2365-6549
DOI:	10.1002/slct.201902373
Popis:	Four mixed cyclodextrin-calixarene nanosponges were tested as possible Drug Delivery Systems, using Tetracycline antibiotic as a suitable model drug. The selected nanosponges featured a different composition ratio between the two host co-monomer components, and the possible presence of ionisable amine or carboxyl groups deriving from chemical post-modification. The pH-dependent absorption and release abilities of the materials were verified; in particular release kinetics showed the occurrence of a simple first-order profile. The antibacterial activity of nanosponge-tetracycline composites suitably prepared under sterile conditions was assayed towards both Gram-positive and Gram-negative typical bacterial strains, showing in some cases an interesting improvement of the biocidal activity.
Databáze:	OpenAIRE
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