Sex Hormone Receptor Expression in Craniopharyngiomas and Association with Tumor Aggressiveness Characteristics
| Autor: | Antonio Martínez-Ortega, Álvaro Flores-Martinez, Eva Venegas-Moreno, Elena Dios, Diego Del Can, Eloy Rivas, Ariel Kaen, Eugenio Cárdenas Ruiz-Valdepeñas, Elena Fajardo, Florinda Roldán, Natividad González-Rivera, Rosario Oliva, José Ignacio Fernández-Peña, Alfonso Soto-Moreno, David A. Cano |
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| Přispěvatelé: | Instituto de Salud Carlos III, European Commission, Junta de Andalucía |
| Rok vydání: | 2022 |
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| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Journal of Clinical Medicine Journal of Clinical Medicine; Volume 11; Issue 1; Pages: 281 Journal of Clinical Medicine, Vol 11, Iss 281, p 281 (2022) |
| Popis: | Craniopharyngiomas (CPs) are rare tumors of the sellar and suprasellar regions of embryonic origin. The primary treatment for CPs is surgery but it is often unsuccessful. Although CPs are considered benign tumors, they display a relatively high recurrence rate that might compromise quality of life. Previous studies have reported that CPs express sex hormone receptors, including estrogen and progesterone receptors. Here, we systematically analyzed estrogen receptor α (ERα) and progesterone receptor (PR) expression by immunohistochemistry in a well-characterized series of patients with CP (n = 41) and analyzed their potential association with tumor aggressiveness features. A substantial proportion of CPs displayed a marked expression of PR. However, most CPs expressed low levels of ERα. No major association between PR and ERα expression and clinical aggressiveness features was observed in CPs. Additionally, in our series, β-catenin accumulation was not related to tumor recurrence. View Full-Text This work was supported by grants from the ISCIII-Subdirección General de Evaluación y Fomento de la Investigación co-funded with Fondos FEDER (PI16/00175 to A.S-M. and D.A.C.) and the Sistema Andaluz de Salud (A-0006-2017 and A-0055-2018 to A.S-M, RC-0006-2018 to D.A.C.). |
| Databáze: | OpenAIRE |
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