Treatment of critical-sized bone defects: clinical and tissue engineering perspectives
| Autor: | Michael J. Gardner, Yunzhi P. Yang, Erika Roddy, Malcolm R. DeBaun, Adam Daoud-Gray |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Osteogenesis Distraction Ilizarov Technique 02 engineering and technology Bone healing Free Tissue Flaps Transplantation Autologous law.invention Fractures Bone 03 medical and health sciences 0302 clinical medicine Tissue engineering law medicine Humans Transplantation Homologous Orthopedics and Sports Medicine Fracture Healing High rate Wound Healing 030222 orthopedics 3D bioprinting Bone Transplantation Tissue Engineering business.industry Bone Cements Treatment options 021001 nanoscience & nanotechnology Surgery Vascularized bone Fibula Distraction osteogenesis Bone Diseases 0210 nano-technology business Stem cell biology |
| Zdroj: | European Journal of Orthopaedic Surgery & Traumatology. 28:351-362 |
| ISSN: | 1432-1068 1633-8065 |
| DOI: | 10.1007/s00590-017-2063-0 |
| Popis: | Critical-sized bone defects are defined as those that will not heal spontaneously within a patient's lifetime. Current treatment options include vascularized bone grafts, distraction osteogenesis, and the induced membrane technique. The induced membrane technique is an increasingly utilized method with favorable results including high rates of union. Tissue engineering holds promise in the treatment of large bone defects due to advancement of stem cell biology, novel biomaterials, and 3D bioprinting. In this review, we provide an overview of the current operative treatment strategies of critical-sized bone defects as well as the current state of tissue engineering for such defects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink