HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature
| Autor: | Erica Linden, Heinz K. Grohs, Smita Jha, Neeraj Saini, Ephraim P. Hochberg, Aliyah R. Sohani |
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| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty Lineage (genetic) business.industry viruses virus diseases Case Report Pleural cavity medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens lcsh:RC254-282 medicine.anatomical_structure Oncology immune system diseases Extranodal lymphoma hemic and lymphatic diseases medicine Primary effusion lymphoma Kaposi Sarcoma Herpes Virus business Body cavity Pathological B cell |
| Zdroj: | Case Reports in Oncological Medicine Case Reports in Oncological Medicine, Vol 2013 (2013) |
| ISSN: | 2090-6706 |
| Popis: | Primary effusion lymphoma (PEL) is a rare extranodal lymphoma that typically presents in a body cavity in the absence of a detectable tumor mass and that occurs predominantly in immunosuppressed individuals. The neoplastic lymphoid cells are frequently infected with human herpes virus 8 (HHV8), also known as Kaposi sarcoma herpes virus (KSHV). We describe two HIV-negative patients who presented with primary effusion lymphoma of B-cell lineage involving the pleural cavity, but whose tumor cells lacked infection by HHV8. We review the English language literature of HHV8-negative PEL of B-cell lineage and compare these lymphomas to HHV8-associated PEL with regard to clinical and pathological characteristics, therapy, and outcome. |
| Databáze: | OpenAIRE |
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