Silver nanoparticle toxicity is related to coating materials and disruption of sodium concentration regulation
| Autor: | Ashutosh Chilkoti, Melissa Chernick, Mark R. Wiesner, David E. Hinton, Kevin W.H. Kwok, Jie Liu, Stella M. Marinakos, Wu Dong |
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| Rok vydání: | 2016 |
| Předmět: |
Silver
Materials science Surface Properties Oryzias Sodium Biomedical Engineering Gene Expression Metal Nanoparticles Nanoparticle chemistry.chemical_element Nanotechnology 02 engineering and technology 010501 environmental sciences Toxicology 01 natural sciences Silver nanoparticle Lethal Dose 50 Gum Arabic Coated Materials Biocompatible Microscopy Electron Transmission Animals Citrates Particle Size Dissolution 0105 earth and related environmental sciences Ions biology Povidone 021001 nanoscience & nanotechnology biology.organism_classification Oxidative Stress chemistry Toxicity Biophysics Silver Nitrate Particle Particle size 0210 nano-technology Water Pollutants Chemical |
| DOI: | 10.6084/m9.figshare.3487091 |
| Popis: | Silver nanoparticles (AgNPs) have been increasingly commercialized and their release into the environment is imminent. Toxicity of AgNP has been studied with a wide spectrum of organisms, yet the mechanism of toxicity remains largely unknown. This study systematically compared toxicity of 10 AgNPs of different particle diameters and coatings to Japanese medaka (Oryzias latipes) larvae to understand how characteristics of AgNP relate to toxicity. Dissolution of AgNPs was largely dependent on particle size, but their aggregation behavior and toxicity were more dependent on coating materials. 96 h lethal concentration 50% (LC50) values correlated with AgNP aggregate size rather than size of individual nanoparticles. Of the AgNPs studied, the dissolved Ag concentration in the test suspensions did not account for all of the observed toxicity, indicating the role of NP-specific characteristics in resultant toxicity. Exposure to AgNP led to decrease of sodium concentration in the tissue and increased expression of Na+/K+ ATPase. Gene expression patterns also suggested that toxicity was related to disruption of sodium regulation and not to oxidative stress. |
| Databáze: | OpenAIRE |
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