CD4+ CD25+ regulatory T-cells role in tumor microenvironment of the squamous cell carcinoma
| Autor: | Cornel Dragoş Cheregi, Mircea Sandor, Ovidiu Laurean Pop, Claudia Teodora Judea Pusta, Pharmacy, Cluj-Napoca, Romania, Mihai-Stefan Muresan, Calin Ionescu, Andrei Pascalau, Zoran Nikin, Florian Dorel Bodog, Carmen Anca Huniadi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
squamous cell carcinoma
CD4-Positive T-Lymphocytes Embryology Lymphocyte chemical and pharmacologic phenomena tumor progression Biology T-Lymphocytes Regulatory Pathology and Forensic Medicine CD4+ Mice Immune system medicine Tumor Microenvironment Cytotoxic T cell Animals IL-2 receptor Tumor microenvironment Original Paper Cluster of differentiation CD25+ therapy response FOXP3 Forkhead Transcription Factors Cell Biology General Medicine microenvironment medicine.anatomical_structure Tumor progression Cancer research Carcinoma Squamous Cell Developmental Biology |
| Zdroj: | Romanian Journal of Morphology and Embryology |
| ISSN: | 2066-8279 1220-0522 |
| Popis: | Introduction: Squamous cell carcinoma (SCC) is the most common skin cancer with a high rate of death. Different lymphocyte populations play an important role in modulating the immune response in the tumor microenvironment. The increase in the proportion of cluster of differentiation (CD)4+ CD25+ regulatory T-cell (Treg) lymphocytes is associated, in different studies, with the increase of the cell multiplication rate. Aim: To analyze the Treg lymphocyte subpopulations and to correlate the results with the presence of the CD8+ cytotoxic T-cell (Tc) lymphocyte population. Materials and Methods: Sixty primary skin SCC specimens were incubated with anti-CD8 (clone SP57) rabbit monoclonal antibody and anti-CD25 (clone 4C9) mouse monoclonal antibody. Results: The ratio of the intratumoral/peritumoral CD4+ CD25+ forkhead box protein p3 (Foxp3) lymphocytes was 0.46, emphasizing that at tumor margins, where tumor aggressiveness is higher, these lymphocytes subpopulations facilitate tumor progression. The comparative analysis of the tumor microenvironment profile revealed that in the case of intratumoral immune response, the number of Tc-type lymphocytes (CD8+) was 3.34 times higher compared to Treg lymphocytes (p |
| Databáze: | OpenAIRE |
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