Primary breast tumours but not lung metastases induce protective anti-tumour immune responses after Treg-depletion
| Autor: | Andrew James Godkin, Andrew Blainey, Anja Bloom, Sarah Nicol Lauder, Jake Scott, Awen Gallimore, Emma Jones, Molly Browne, E. Hughes, Michelle Somerville, Ann Ager, Kathryn Smart |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Lung Neoplasms Mouse medicine.medical_treatment Immunology T cells Triple Negative Breast Neoplasms Tregs chemical and pharmacologic phenomena Disease T-Lymphocytes Regulatory Lymphocyte Depletion Metastasis Mice 03 medical and health sciences Lymphocytes Tumor-Infiltrating Breast cancer 0302 clinical medicine Immune system medicine Animals Immunology and Allergy Lung business.industry FOXP3 Cancer Forkhead Transcription Factors Immunotherapy Resection medicine.disease 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research Female Original Article business |
| Zdroj: | Cancer Immunology, Immunotherapy |
| ISSN: | 1432-0851 0340-7004 |
| Popis: | Although metastatic disease is responsible for the majority of cancer deaths, tests of novel immunotherapies in mouse tumour models often focus on primary tumours without determining whether these therapies also target metastatic disease. This study examined the impact of depleting Foxp3+ regulatory T cells (Treg), on lung metastases, using a mouse model of breast cancer. After Treg-depletion, generation of an immune response to the primary tumour was a critical determinant for limiting development of metastasis. Indeed, resection of the primary tumour abrogated any effect of Treg-depletion on metastases. In addition, whilst the immune response, generated by the primary tumour, prevented metastases development, it had little impact on controlling established disease. Collectively, the data indicate that metastatic cells in the lung are not controlled by immune responses induced by the primary tumour. These findings indicate that targeting Tregs alone will not suffice for treating lung metastases. Electronic supplementary material The online version of this article (10.1007/s00262-020-02603-x) contains supplementary material, which is available to authorised users. |
| Databáze: | OpenAIRE |
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