Clinical Staging in Reye Syndrome
| Autor: | Frederick H. Lovejoy, Michael J. Bresnan, James N. Wood, Patricia C. Adams, Arnold L. Smith, David I. Victor |
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| Rok vydání: | 1974 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Pediatrics Adolescent Intracranial Pressure medicine.medical_treatment Exchange Transfusion Whole Blood Exchange transfusion Brain Edema Liver Function Tests Ammonia Seizures medicine Humans Reye's syndrome Mannitol Reye Syndrome Stage (cooking) Child Glucocorticoids Intracranial pressure Prothrombin time Brain Diseases medicine.diagnostic_test business.industry Fatty liver Infant Cerebrospinal Fluid Proteins Electroencephalography Prognosis medicine.disease Surgery Fatty Liver Glucose Child Preschool Pediatrics Perinatology and Child Health Prothrombin Time Female business Liver function tests |
| Zdroj: | Archives of Pediatrics & Adolescent Medicine. 128:36 |
| ISSN: | 1072-4710 |
| DOI: | 10.1001/archpedi.1974.02110260038007 |
| Popis: | Of 40 patients with Reye syndrome hospitalized over a three-year period, 17 died, while two survivors have severe neurologic impairment. The illness progressed through five stages, each correlating with progressive rostral-caudal central nervous system involvement. Clinical indexes suggesting a poor outcome included an initial blood ammonia concentration > 300μg/100 ml; a rapid progression through the first three clinical stages; the onset of seizure activity in stage III; increased cerebrospinal fluid pressure in stage IV; and a prothrombin time in stage III that was 13 or more seconds longer than that of the control. In patients with an illness beyond stage III, death or severe neurological impairment occurred. The mortality did not seem to be lowered by exchange transfusion or conventional medical therapeutic means of reducing increased intracranial pressure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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