Effect of obesity on patient-reported outcomes in sarcoidosis
| Autor: | Aleksandra Dudvarski-Ilić, Vladimir Zugic, Mira Vukovic, Mihailo Stjepanovic, Elyse E. Lower, Spasoje Popevic, Maja Omcikus, Branislav Gvozdenovic, R P Baughman, Snežana Filipović, Jelica Videnovic-Ivanov, Violeta Mihailovic-Vucinic |
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| Rok vydání: | 2013 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry Adult Male Vital capacity medicine.medical_specialty Health Status Vital Capacity Body Mass Index Sarcoidosis Pulmonary Predictive Value of Tests Risk Factors Internal medicine Forced Expiratory Volume Surveys and Questionnaires medicine Odds Ratio Humans Obesity Lung Fatigue Chi-Square Distribution medicine.diagnostic_test business.industry Case-control study Odds ratio Middle Aged medicine.disease Prognosis Infectious Diseases Dyspnea Logistic Models Predictive value of tests Case-Control Studies Multivariate Analysis Female Sarcoidosis business Body mass index Chi-squared distribution Serbia Immunosuppressive Agents |
| Zdroj: | The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 17(4) |
| ISSN: | 1815-7920 |
| Popis: | OBJECTIVES To assess the impact of high body mass index (BMI) on patient-reported outcomes in sarcoidosis patients and healthy persons. METHODS In this case-control study, we investigated symptoms of fatigue and dyspnoea, health status, BMI and spirometric tests in 184 sarcoidosis patients and the same number of sex- and age-matched healthy subjects. Fatigue was assessed using the fatigue scale (FS), dyspnoea was determined by the baseline dyspnoea index (BDI) and health status was measured using the respiratory-specific St George's Respiratory Questionnaire (SGRQ). RESULTS There were significantly more subjects with increased BMI (≥25 kg/m(2)) among the sarcoidosis patients than among the healthy volunteers ((2) 37.675, P < 0.01). Sarcoidosis patients also had a greater probability of having a higher BMI (P < 0.01, OR 1.18, 95%CI 1.071.3). We found significantly lower BDI scores and forced expiratory volume in 1 s/forced vital capacity, as well as higher total SGRQ and total FS scores in sarcoidosis patients than in healthy individuals (P < 0.01 for all differences). CONCLUSION Sarcoidosis significantly reduces patients' health status, both independently and also due to increased BMI. Reduction in BMI may contribute to improved spirometry results and health status of patients with sarcoidosis. |
| Databáze: | OpenAIRE |
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