Postmenopausal hormone therapy and mammographic breast density
| Autor: | Lorenza Driul, M. Della Martina, M. Bazzocchi, C. Zuiani, A Ianni, G. Fabiani, Diego Marchesoni |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Norpregnenes medicine.medical_treatment Mammary gland Urology Breast Neoplasms Medroxyprogesterone Acetate Tibolone Placebo General Biochemistry Genetics and Molecular Biology Estrogen Receptor Modulators Humans Medicine Mammography Medroxyprogesterone acetate Single-Blind Method Breast Prospective Studies Gynecology Estrogens Conjugated (USP) medicine.diagnostic_test business.industry Estrogen Replacement Therapy Obstetrics and Gynecology Estrogens Hormone replacement therapy (menopause) Middle Aged Postmenopause Treatment Outcome medicine.anatomical_structure Hormonal therapy Female Hormone therapy business Follow-Up Studies medicine.drug |
| Zdroj: | Maturitas. 53:59-64 |
| ISSN: | 0378-5122 |
| DOI: | 10.1016/j.maturitas.2005.02.010 |
| Popis: | The aim of this study was to evaluate the effects of different types of hormone replacement therapy (HRT) on mammographic density.In a prospective 1-year study, 103 postmenopausal women were randomized to receive tibolone 2.5 mg/die, continuous conjugated equine estrogens 0.625 mg/die plus medroxyprogesterone acetate (MPA) 5mg/die or placebo. Mammograms were performed at baseline and after 12 months of treatment. Mammographic density was quantified according to the Wolfe classification.After 12 months of HRT 16 of the 35 patients (45.1%) receiving continuous combined hormonal therapy showed an increase of breast density change in the Wolfe classification. After treatment with tibolone, an up grading in breast density, according to Wolfe's classification, was found in 2 of the 43 patients (2.3%). No changes were recorded in the 25 patients of the control group. The difference between the group treated with continuous combined hormonal therapy and the control group was highly significant (p0.001). The difference in breast density between patients in treatment with tibolone and the control group was not statistically significant (p=0.34).Continuous combination HRT may be more commonly associated with an increase of mammography density than tibolone treatment. |
| Databáze: | OpenAIRE |
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