RNA Interference Mutant Induction In Vivo Demonstrates the Essential Nature of Trypanosome Flagellar Function during Mammalian Infection

Autor:	Samantha Griffiths, Michael L. Ginger, Siamon Gordon, Keith Gull, Philip R. Taylor, Neil Portman
Rok vydání:	2007
Předmět:	Trypanosoma brucei brucei Mutant RNA Motility Articles General Medicine Flagellum Biology Microbiology Cell biology Mice Trypanosomiasis African Cell Movement Flagella In vivo RNA interference Animals Humans RNA Interference RNA Small Interfering Molecular Biology Function (biology) Cytokinesis
Zdroj:	Eukaryotic Cell. 6:1248-1250
ISSN:	1535-9786 1535-9778
DOI:	10.1128/ec.00110-07
Popis:	We demonstrate that trypanosomes compromised in flagellar function are rapidly cleared from infected mice. Analysis of the PFR2 bloodstream RNA interference mutant revealed that defective cell motility occurred prior to cytokinesis failure. This validation provides a paradigm for the flagellum as a target for future assays and interventions against this human pathogen.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781d3696aae20a96065bec2dc55bb501 https://doi.org/10.1128/ec.00110-07 Zobrazit plný text záznamu