Silymarin inhibits the lipogenic pathway and reduces worsening of non-alcoholic fatty liver disease (NAFLD) in mice

Autor: Luana Cristina Faria Carvalho, Flávia Monteiro Ferreira, Bruna Vidal Dias, Daniela Couto de Azevedo, Gustavo Henrique Bianco de Souza, Matheus Marque Milagre, Marta de Lana, Paula Melo de Abreu Vieira, Cláudia Martins Carneiro, Sílvia de Paula-Gomes, Silvia Dantas Cangussu, Daniela Caldeira Costa
Rok vydání: 2022
Předmět:
Zdroj: Archives of Physiology and Biochemistry. :1-15
ISSN: 1744-4160
1381-3455
DOI: 10.1080/13813455.2022.2138445
Popis: The role of silymarin in hepatic lipid dysfunction and its possible mechanisms of action were investigated.To evaluate the effects of silymarin on hepatic and metabolic profiles in mice fed with 30% fructose for 8 weeks.We evaluated the antioxidant profile of silymarin; mice consumed 30% fructose and were treated with silymarin (120Silymarin contains high levels of phenolic compounds and flavonoids and exhibited significant antioxidant capacityThese results suggest that silymarin reduces worsening of NAFLD.
Databáze: OpenAIRE
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