MTHFR (C677T) polymorphism and PR (PROGINS) mutation as genetic factors for preterm delivery, fetal death and low birth weight: A Northeast Indian population based study
| Autor: | Purabi Deka Bose, Chandana Ray Das, Ratul Datta, Diptika Tiwari, Somdatta Das, Sujoy Bose |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Pediatrics MTHFR C677T polymorphism Gene mutation Article Progesterone receptor Genetics medicine Mthfr c677t Preterm delivery Northeast India Genetics (clinical) Pregnancy Negative pregnancy outcome biology Obstetrics business.industry Indian population medicine.disease digestive system diseases Low birth weight Methylenetetrahydrofolate reductase PR (PROGINS) mutation biology.protein medicine.symptom business |
| Zdroj: | Meta Gene |
| ISSN: | 2214-5400 |
| DOI: | 10.1016/j.mgene.2014.12.002 |
| Popis: | Preterm delivery (PTD) is one of the most significant contributors to neonatal mortality, morbidity, and long-term adverse consequences for health; with highest prevalence reported from India. The incidence of PTD is alarmingly very high in Northeast India. The objective of the present study is to evaluate the associative role of MTHFR gene polymorphism and progesterone receptor (PR) gene mutation (PROGINS) in susceptibility to PTD, negative pregnancy outcome and low birth weights (LBW) in Northeast Indian population. Methods A total of 209 PTD cases {extreme preterm ( Highlights • This is the first study involving the analysis of genetic risk factors associated with preterm delivery in Northeast India. • MTHFR C677T polymorphism and PR (PROGINS) mutation in predisposition to preterm delivery, negative pregnancy outcome and low birth weight. • MTHFR C677T polymorphism may be used as a prognostic marker to stratify subpopulation of pregnancy cases predisposed to PTD; thereby controlling the risks associated with PTD. |
| Databáze: | OpenAIRE |
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