Lethal and sublethal effects on the progeny of male rats treated with methadone
| Autor: | Justin M. Joffe, John M. Peterson, Lester F. Soyka |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Litter (animal) Offspring medicine.medical_treatment Birth weight Physiology Growth Avoidance response Biology Toxicology Open field Sexual Behavior Animal chemistry.chemical_compound Seminal vesicle medicine Animals Birth Weight Weaning Saline Pharmacology Behavior Animal business.industry Body Weight Sire Meth Rats Fertility medicine.anatomical_structure Animals Newborn chemistry Pediatrics Perinatology and Child Health Female business Methadone medicine.drug |
| Zdroj: | Toxicology and Applied Pharmacology. 45:797-807 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(78)90171-0 |
| Popis: | Fifteen male rats were treated with methadone-HCl (Meth) at 10 mg/kg sc per day for 12 days and an equal number received injections of sterile distilled water. Each male was caged with four untreated females each night. A necropsy was performed on male rats following the period of mating and the litter sizes, birth and weaning weights, and survival to 21 days (neonatal mortality) of their progeny were evaluated. METH-treated males had a reduction in body and seminal vesicle weights and in mating frequency, confirming prior studies. Progeny of METH-treated males (507 pups) were of lower average birth weight than the 276 controls. In addition, it was found that prior copulation had a differential effect, resulting in slightly heavier control pups but significantly decreased birth weights in the METH group. Neonatal mortality of the METH progeny was significantly increased, with 18.2% dead by 21 days compared to 9.5% of the controls (p < 0.01). The present data indicated that mortality was related in a complex fashion to number of drug exposures and previous sexual experience of the sire and that male offspring were particularly affected. Ponderal growth of survivors from litters with high neonatal death rates was inhibited, with females being significantly lighter at 75 and 132 days of age. Open-field defecation scores were significantly different at 2 but not at 4 months of age, but no differences in acquisition of a conditioned avoidance response were noted. No differences in litter size, neonatal mortality, or birth or weaning weights as a result of METH administration were found in the F2 generation. These results, together with previous data from our laboratory, establish that there are lethal, sublethal, and possibly delayed effects on the progeny of male rats treated with methadone. |
| Databáze: | OpenAIRE |
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