Human Papillomavirus Infection, p16INK4a Expression and Genetic Alterations in Vietnamese Cervical Neuroendocrine Cancer
| Autor: | Quang Ngoc Nguyen, Hung Phi Nguyen, Linh Dieu Vuong, To Van Ta, Toan Trung Tran, Van-Long Truong |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Neuroblastoma RAS viral oncogene homolog
HPV Viral Oncogene medicine.disease_cause 03 medical and health sciences 0302 clinical medicine p16INK4a Cervical Neuroendocrine Carcinoma Neuroblastoma medicine Cervix neoplasms Cervical cancer 030219 obstetrics & reproductive medicine business.industry HPV infection General Medicine medicine.disease neuroendocrine cervical cancer p53 mutation medicine.anatomical_structure NRAS mutation 030220 oncology & carcinogenesis Cancer research KRAS business Brief Communications |
| Zdroj: | The Malaysian Journal of Medical Sciences : MJMS |
| ISSN: | 2180-4303 1394-195X |
| Popis: | Neuroendocrine cervical cancer is a rare subtype of cervical cancer with a highly aggressive malignancy. This study was conducted to analyse the human papillomavirus (HPV) infection and molecular abnormalities in Vietnamese neuroendocrine carcinomas of the uterine cervix. HPV genotyping and p53 mutations were examined using polymerase chain reaction (PCR)-based direct sequencing. Mutations of epidermal growth factor receptor (EGFR), Kirsten rat sarcoma (KRAS), neuroblastoma RAS viral oncogene homolog (NRAS) and v-Raf murine sarcoma viral oncogene homolog B (BRAF) were identified using commercial kits. Four high-risk HPV genotypes were identified in 26 (86.7%) out of a total of 30 tumours. The prevalence of HPV 16, 18, 31 and 45 was 20.0%, 50.0%, 20.0% and 36.7%, respectively. Overexpression of p16INK4a was observed in 93.3% of cases and was significantly correlated with high-risk HPV infections. Furthermore, p53 and NRAS mutations were detected in five (16.7%) and one (3.3%) cases, respectively, whereas no EGFR, KRAS or BRAF mutations were observed. These results demonstrate that high-risk HPV infection may be an important oncogenic factor for the development and progression of cervical neuroendocrine carcinoma. |
| Databáze: | OpenAIRE |
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