Treatment of feline mammary tumours using chemotherapy, surgery and a COX-2 inhibitor drug (meloxicam): a retrospective study of 23 cases (2002-2007)
| Autor: | J. C. Cartagena, J. Engel, J. F. Borrego |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Mammary gland Thiazines Antineoplastic Agents Mammary Neoplasms Animal Cat Diseases Meloxicam medicine Animals Doxorubicin Prospective cohort study Retrospective Studies Chemotherapy Cyclooxygenase 2 Inhibitors General Veterinary business.industry Retrospective cohort study medicine.disease Surgery Thiazoles medicine.anatomical_structure Cats Adenocarcinoma Female Azotemia business medicine.drug |
| Zdroj: | Veterinary and Comparative Oncology. 7:213-221 |
| ISSN: | 1476-5829 1476-5810 |
| DOI: | 10.1111/j.1476-5829.2009.00194.x |
| Popis: | The efficacy of a treatment combination of a COX-2 inhibitor (meloxicam), chemotherapy and surgery in 23 cats with histologically confirmed mammary gland adenocarcinoma was evaluated. All of the cases underwent an aggressive surgery with concurrent doxorubicin-based chemotherapy. Meloxicam was given orally starting the day after surgery and was continued indefinitely. Serum renal parameters were measured every 3-5 months. Three cats developed azotemia, whereas in four other renal parameters increased but remained within normal limit. The Kaplan-Meier median survival time was 460 days. The Kaplan-Meier median disease free interval was 269 days. The survival times are similar to other studies, not supporting the use of this treatment combination. Prospective studies with a higher number of cases are warranted to investigate the utility of this multimodality protocol for the treatment of feline mammary tumours. |
| Databáze: | OpenAIRE |
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