The effect of 24 months recombinant human growth hormone (rh-GH) on LDL cholesterol, triglyceride-rich lipoproteins and apo [a] in hypopituitary adults previously treated with conventional replacement therapy
| Autor: | F. L. Hew, Frank P. Alford, James D. Best, David N O'Neal |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Apolipoprotein B Hormone Replacement Therapy Endocrinology Diabetes and Metabolism Lipoproteins Apolipoproteins A Hypopituitarism Growth hormone deficiency chemistry.chemical_compound Endocrinology Internal medicine medicine Humans Insulin biology Triglyceride medicine.diagnostic_test business.industry Cholesterol Human Growth Hormone Cholesterol LDL Middle Aged medicine.disease chemistry Low-density lipoprotein Growth Hormone biology.protein Body Composition lipids (amino acids peptides and proteins) Female business Lipid profile Lipoprotein |
| Zdroj: | Growth hormoneIGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 9(3) |
| ISSN: | 1096-6374 |
| Popis: | Hypopituitary adults receiving conventional hormone replacement therapy are reported to have increased cardiovascular mortality. Previous studies indicate that these patients have several abnormalities in lipoprotein metabolism, including reduced low density lipoprotein (LDL) uptake and impaired metabolism of triglyceride-rich lipoproteins. The effects of 24 months of 0.21 IU/kg per week recombinant growth hormone (rh-GH) on the lipoprotein profiles of 22 GH-deficient adults were studied. Samples were collected after a 12-h fast at baseline and 24 months. Total cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol, LDL cholesterol, apolipoprotein (apo) A, apo B and apo [a] were determined by routine laboratory methods. LDL particle size was determined by non-denaturing gradient gel electrophoresis. Visceral adiposity was determined by dual energy X-ray absorptiometry (DEXA). Insulin sensitivity was measured in a subset of 17 subjects using a two-stage hyperinsulinaemic-euglycaemic clamp. Significant reductions were observed in total cholesterol (5.3 +/- 0. 17 vs 4.9 +/- 0.23 mmol/l;P |
| Databáze: | OpenAIRE |
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