Interfacial properties and micellization of triblock poly(ethylene glycol)-poly(ε-caprolactone)-polyethyleneimine copolymers

Autor: Yiguang Jin, Ji Li, Yitian Du, Shixuan Cheng, Xian-Rong Qi, Yanxia Zhou, Hai-Tao Su
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Original article
Nanostructure
Materials science
Langmuir films
DTX
docetaxel
SLS
static light scattering
macromolecular substances
Isothermal process
Rg
gyration radius
Hydrophobic effect
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Np
nano-assembly numbers
PEG
poly(ethylene glycol)
Copolymer
General Pharmacology
Toxicology and Pharmaceutics
Rh
hydrodynamic radius
030304 developmental biology
DLS
dynamic light scattering
LB
Langmuir–Blodgett
PEI
polyethyleneimine
0303 health sciences
Hydrogen bond
PCL
poly(ε-caprolactone)
lcsh:RM1-950
CMC
critical micelle concentration
technology
industry
and agriculture
TEM
transmission electron microscope
Self-assembly
AFM
atomic force microscope
GPC
gel permeation chromatography
Block copolymers
Molecular arrangement
lcsh:Therapeutics. Pharmacology
chemistry
Chemical engineering
030220 oncology & carcinogenesis
Drug delivery
Amin
critical molecular area
Nagg
polymer aggregation number
Caprolactone
PDI
polydispersity
Zdroj: Acta Pharmaceutica Sinica B, Vol 10, Iss 6, Pp 1122-1133 (2020)
Acta Pharmaceutica Sinica. B
ISSN: 2211-3835
Popis: This study aimed to explore the link between block copolymers’ interfacial properties and nanoscale carrier formation and found out the influence of length ratio on these characters to optimize drug delivery system. A library of diblock copolymers of PEG-PCL and triblock copolymers with additional PEI (PEG-PCL-PEI) were synthesized. Subsequently, a systematic isothermal investigation was performed to explore molecular arrangements of copolymers at air/water interface. Then, structural properties and drug encapsulation in self-assembly were investigated with DLS, SLS and TEM. We found the additional hydrogen bond in the PEG-PCL-PEI contributes to film stability upon the hydrophobic interaction compared with PEG-PCL. PEG-PCL-PEI assemble into smaller micelle-like (such as PEG-PCL4006-PEI) or particle-like structure (such as PEG-PCL8636-PEI) determined by their hydrophilic and hydrophobic block ratio. The distinct structural architectures of copolymer are consistent between interface and self-assembly. Despite the disparity of constituent ratio, we discovered the arrangement of both chains guarantees balanced hydrophilic–hydrophobic ratio in self-assembly to form stable construction. Meanwhile, the structural differences were found to have significant influence on model drugs incorporation including docetaxel and siRNA. Taken together, these findings indicate the correlation between molecular arrangement and self-assembly and inspire us to tune block compositions to achieve desired nanostructure and drug loading.
Graphical abstract This paper found the correlation between molecular arrangement and self-assembly and inspired us to tune block compositions to achieve desired nanostructure and drug loading.Image 1
Databáze: OpenAIRE
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