Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review)
| Autor: | Cuauhtemoc Licona Cassani, María Isabela Avila Rodríguez, José Manuel Aguilar‑Yañez, David Meléndez‑Martínez, Mirna Lorena Sánchez, Jorge Benavides |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Proteases medicine.medical_treatment maggot secretory products fish epithelial mucus Context (language use) Review Matrix metalloproteinase Bioinformatics General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Wound care 0302 clinical medicine matrix metalloproteases medicine purl.org/becyt/ford/3.4 [https] General Pharmacology Toxicology and Pharmaceutics Protease integumentary system Maggot business.industry General Neuroscience General Medicine FISH-EPITHELIAL-MUCUS Mucus enzymatic wound treatment PROTEASES 030104 developmental biology 030220 oncology & carcinogenesis WOUND-HEALING purl.org/becyt/ford/3 [https] METALLOPROTEASES business Wound healing snake venom proteases |
| Zdroj: | Biomedical Reports CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 2049-9442 2049-9434 |
| Popis: | Skin wounds have been extensively studied as their healing represents a critical step towards achieving homeostasis following a traumatic event. Dependent on the severity of the damage, wounds are categorized as either acute or chronic. To date, chronic wounds have the highest economic impact as long term increases wound care costs. Chronic wounds affect 6.5 million patients in the United States with an annual estimated expense of $25 billion for the health care system. Among wound treatment categories, active wound care represents the fastest‑growing category due to its specific actions and lower costs. Within this category, proteases from various sources have been used as successful agents in debridement wound care. The wound healing process is predominantly mediated by matrix metalloproteinases (MMPs) that, when dysregulated, result in defective wound healing. Therapeutic activity has been described for animal secretions including fish epithelial mucus, maggot secretory products and snake venom, which contain secreted proteases (SPs). No further alternatives for use, sources or types of proteases used for wound healing have been found in the literature to date. Through the present review, the context of enzymatic wound care alternatives will be discussed. In addition, substrate homology of SPs and human MMPs will be compared and contrasted. The purpose of these discussions is to identify and propose the stages of wound healing in which SPs may be used as therapeutic agents to improve the wound healing process. Fil: Avila Rodríguez, María Isabela. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México Fil: Meléndez Martínez, David. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México Fil: Licona Cassani, Cuauhtemoc. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México Fil: Aguilar Yañez, José Manuel. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México. Scicore Medical SAPI de CV; México Fil: Benavides, Jorge. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México Fil: Sanchez, Mirna Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina |
| Databáze: | OpenAIRE |
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