Changing Patterns of Prognosticators During 15-Year Follow-Up of Advanced Gastric Cancer after Radical Gastrectomy and Adjuvant Chemotherapy: A 15-Year Follow-Up Study at a Single Korean Institute
| Autor: | Byung Soo Kim, Sung Hoon Noh, Hyun Cheol Chung, Jae Kyung Roh, Nae Choon Yoo, Yong Wha Moon, Sun Young Rha, Hei Cheul Jeung |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Adjuvant chemotherapy medicine.medical_treatment Adenocarcinoma Disease-Free Survival Gastrectomy Stomach Neoplasms Surgical oncology Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Survivors Survival rate Aged Neoplasm Staging Chemotherapy business.industry General surgery Cancer Neoplasms Second Primary Middle Aged Prognosis medicine.disease Combined Modality Therapy Survival Rate Natural history Chemotherapy Adjuvant Doxorubicin Disease Progression Lymph Node Excision Female Surgery Fluorouracil Neoplasm Recurrence Local business Adjuvant Follow-Up Studies |
| Zdroj: | Annals of Surgical Oncology. 14:2730-2737 |
| ISSN: | 1534-4681 1068-9265 |
| DOI: | 10.1245/s10434-007-9479-4 |
| Popis: | We evaluated the long-term natural history of gastric cancer after radical gastrectomy and adjuvant chemotherapy through a 15-year follow-up study at a single institute.Five hundred patients with advanced gastric adenocarcinoma who received radical gastrectomy and adjuvant chemotherapy were included in this long-term follow-up study. Patients were evaluated by imaging studies and upper gastrointestinal series or endoscopy every 6 months until the 10th year after surgery. Since then, the patients have been followed yearly in the same manner.The median follow-up period was 190.5 months. The recurrence rate in 5-year survivors was 10.8%. The dominant recurrence pattern was peritoneal carcinomatosis within 5 years and distant metastasis after 5 years post gastrectomy. Tumor stage was a clear-cut prognosticator within 5 years post gastrectomy, but was no longer informative in 5-10 years. At this period, only stage IV (IB-IIIB vs IVM0) was a significantly poor prognosticator. After 10 years, second primary cancer (seven cases) became as important an issue as recurrence of primary gastric cancer (six cases).In patients with gastric carcinoma treated with radical gastrectomy and adjuvant chemotherapy, late recurrence after 5 years post gastrectomy was not rare. Prognosticators were varied depending on the length of time after surgery. Tumor factors including stage were prognosticators within 5 years post gastrectomy, but tumor factors except stage IV had no prognostic value after 5 years. In the 5-10 years post gastrectomy, only stage IV (IB-IIIB vs IVM0) was a poor prognosticator. Also, after 10 years, there were no prognosticators. |
| Databáze: | OpenAIRE |
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