ATP‐dependent bacterial transporters and cystic fibrosis: analogy between channels and transporters
| Autor: | Harold Lecar, Giovanna Ferro-Luzzi Ames |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cystic Fibrosis
ATPase Molecular Sequence Data Biological Transport Active Biology Biochemistry Cystic fibrosis Ion Channels Adenosine Triphosphate Genetics medicine Amino Acid Sequence Molecular Biology Permease Transporter Periplasmic space Membrane transport medicine.disease Biological Evolution Mechanism of action Chloride channel biology.protein medicine.symptom Carrier Proteins Biotechnology |
| Zdroj: | The FASEB Journal. 6:2660-2666 |
| ISSN: | 1530-6860 0892-6638 |
| Popis: | The traffic ATPases superfamily includes known transporters, both prokaryotic and eukaryotic, including the medically important proteins, P-glycoprotein, and the cystic fibrosis gene product (CFTR), which is known to be a Cl- channel. The structure and mechanism of action of the best-studied members of the superfamily, the periplasmic permeases, are described and related to that of CFTR and eukaryotic traffic ATPases in general. The contention is put forward that the distinction between the architecture and mechanisms of action of channels and transporters is blurred. |
| Databáze: | OpenAIRE |
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