Host Adaptation Predisposes Pseudomonas aeruginosa to Type VI Secretion System-Mediated Predation by the Burkholderia cepacia Complex
| Autor: | Andrew I. Perault, Matthew C. Wolfgang, Courtney E. Chandler, Peggy A. Cotter, Robert K. Ernst, David A. Rasko |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Adolescent Cystic Fibrosis Burkholderia cenocepacia Biology Host Adaptation medicine.disease_cause Microbiology Cystic fibrosis Article Young Adult 03 medical and health sciences 0302 clinical medicine Virology parasitic diseases medicine Animals Humans Pseudomonas Infections Secretion Child Lung 030304 developmental biology Type VI secretion system 0303 health sciences Bacteria integumentary system Coinfection 030306 microbiology Pseudomonas aeruginosa Burkholderia cepacia complex fungi Infant Burkholderia Infections Type VI Secretion Systems Preview medicine.disease biology.organism_classification 3. Good health Child Preschool Superinfection Host-Pathogen Interactions Mutation Parasitology Host adaptation 030217 neurology & neurosurgery |
| Zdroj: | Cell Host & Microbe Cell Host Microbe |
| DOI: | 10.1101/2020.04.10.036012 |
| Popis: | SUMMARYPseudomonas aeruginosa (Pa) and Burkholderia cepacia complex (Bcc) species are opportunistic lung pathogens of individuals with cystic fibrosis (CF). While Pa can initiate long-term infections in younger CF patients, Bcc infections only arise in teenagers and adults. Both Pa and Bcc use type VI secretion systems (T6SS) to mediate interbacterial competition. Here, we show that Pa isolates from teenage/adult CF patients, but not those from young CF patients, are outcompeted by the epidemic Bcc isolate Burkholderia cenocepacia strain AU1054 (BcAU1054) in a T6SS-dependent manner. The genomes of susceptible Pa isolates harbor T6SS-abrogating mutations, the repair of which, in some cases, rendered the isolates resistant. Moreover, seven of eight Bcc strains outcompeted Pa strains isolated from the same patients. Our findings suggest that certain mutations that arise as Pa adapts to the CF lung abrogate T6SS activity, making Pa and its human host susceptible to potentially fatal Bcc superinfection. |
| Databáze: | OpenAIRE |
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