Myocardial distribution of 18F-FDG and 99mTc-sestamibi on dual-isotope simultaneous acquisition SPET compared with PET
| Autor: | Masamichi Matsudaira, Noboru Takekoshi, Ichiro Matsunari, Kinichi Hisada, Kenichi Nakajima, Norihisa Tonami, Tatsuya Yoneyama, Stephan G. Nekolla, Sugako Kanayama, Junichi Taki |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Technetium Tc 99m Sestamibi Heart Ventricles Flow tracer Statistics as Topic Coronary Artery Disease Sensitivity and Specificity Technetium (99mTc) sestamibi Basal (phylogenetics) Positron Ammonia Fluorodeoxyglucose F18 TRACER medicine Humans Tissue Distribution Radiology Nuclear Medicine and imaging Tomography Emission-Computed Single-Photon Fluorodeoxyglucose Nitrogen Radioisotopes medicine.diagnostic_test business.industry Reproducibility of Results General Medicine Middle Aged Positron emission tomography Female Tomography Radiopharmaceuticals business Nuclear medicine Tomography Emission-Computed medicine.drug |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging. 29:1357-1364 |
| ISSN: | 1619-7089 1619-7070 |
| Popis: | A dual-isotope simultaneous acquisition (DISA) single-photon emission tomography (SPET) protocol with fluorine-18 fluorodeoxyglucose ((18)F-FDG) and a technetium-99m labelled flow tracer is attractive because it permits assessment of both myocardial glucose utilisation and flow within a single study. Differences in physical and physiological characteristics between (18)F-FDG and the (99m)Tc-labelled flow tracer, however, may cause differences in myocardial activity distribution between the agents. The aim of this study was to investigate the relation between the myocardial distribution of (18)F-FDG and a (99m)Tc-labelled flow tracer on DISA SPET in comparison with nitrogen-13 ammonia/(18)F-FDG positron emission tomography (PET). Nine normal volunteers without cardiac disease and ten patients with known coronary artery disease (CAD) underwent (13)N-ammonia/(18)F-FDG PET and (99m)Tc-sestamibi/(18)F-FDG DISA SPET. Using a semiquantitative polar map approach, the left ventricular myocardium was divided into nine segments, and relative regional activity was calculated for each segment. A segment was considered to have concordant uptake between (18)F-FDG and flow tracer if the difference in measured regional activity between the tracers wasor =10% of peak activity, and the percentage of concordant segments was calculated for each subject. There was a good overall concordance of myocardial activity between the agents on DISA SPET (84.0%+/-14.8%) in normals, which was comparable to that seen on PET (86.4%+/-14.5%, NS vs DISA SPET). However, the myocardial activity distributions of (18)F-FDG and flow tracer were not identical in that reduced flow tracer activity was seen in the basal segments on DISA SPET in both normals and CAD patients. It is concluded that there is good overall concordance of activity between (18)F-FDG and flow tracer in normal myocardium on DISA SPET, which is comparable to that on PET, supporting the use of combined (99m)Tc-flow tracer/(18)F-FDG imaging for the detection of viable myocardium. However, there is a difference in the myocardial activity distribution between the agents in both normals and CAD patients, the difference being particularly evident in the basal segments. Therefore, careful image interpretation that takes into consideration the different normal activity distribution between the tracers and/or a tracer-specific normal database is necessary for comparison with patient studies. |
| Databáze: | OpenAIRE |
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